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Name the 3 Ascending (Sensory) Pathways
Dorsal Column Medial Lemniscus Tract
Spinocerebellar Tract
Spinothalamic Tract
Name the 5 Descending (Motor) Tracts
Extrapyramidal Tracts:
Reticulospinal Tract
Vestibulospinal Tract
Rubrospinal Tract
Tectospinal Tract
Pyramidal Tract:
Corticospinal tract
What are the DCML tract sensory receptors?
Mechanorecepetors
meissners corpuscles
merkels discs
pacinian corpuscles
ruffini endings
Proprioception
muscle spindles
golgi tendon organs
What is the DCML pathway responsible for?
fine (discriminative) touch
vibration sensation
proprioception
stereogenosis
Define Proprioception
Proprioception is the body's ability to sense its position, movement, and orientation in space.
Define stereogenosis
Stereognosis is the ability to recognize and identify objects by touch alone, without the use of vision
What is a mechanoreceptor?
Mechanoreceptors are specialized sensory receptors that respond to mechanical stimuli such as pressure, vibration, and stretch.
Where are meissner’s corpuscles located?
Found in the skin, particularly in the fingertips, palms, soles, and lips.
What do meissner’s corpuscles do?
Detect light touch, vibration, and texture.
What are meissner’s corpuscles adaptation?
Rapidly adapting, meaning they respond quickly to changes in stimuli but stop firing if the stimulus remains constant.
Where are Merkel’s Discs located?
Located in the epidermis (outer layer of skin), especially in the fingertips and lips.
What is the function of Merkel’s discs?
Detect sustained pressure, texture, and fine details.
What is Merkel’s disc adaptation?
Slowly adapting, meaning they continue to respond as long as the stimulus is applied.
Where are Pacinian Corpuscles located?
Found deep in the skin, as well as in muscles, joints, and internal organs.
What is the function of Pacinian Corpuscles?
Detect deep pressure, vibration, and proprioceptive information.
What is the adaptation of Pacinian Corpuscles?
Rapidly adapting, making them ideal for detecting changes in pressure or vibration.
Where are Ruffini endings located?
Located in the dermis and joint capsules.
What is the function of Ruffini endings?
Detect skin stretch, sustained pressure, and joint movement.
What is the adaptation of Ruffini endings?
Slowly adapting, providing continuous feedback about skin stretch and joint position.
Where are muscle spindles located?
Found within skeletal muscles.
What is the function of muscle spindles?
Detect changes in muscle length and the rate of stretch.
What is the role of muscle spindles?
Help regulate muscle tone and coordinate movement by triggering reflexes, like the stretch reflex (e.g., knee-jerk reaction).
Where are golgi tendon organs located?
Located at the junction between muscles and tendons.
What is the function of golgi tendon organs?
Detect tension within a muscle during contraction.
What is the role of golgi tendon organs?
Prevent muscle damage by triggering the Golgi tendon reflex, which relaxes the muscle when excessive force is detected.
Explain the First-Order Neurons (Sensory Receptors ➔ Medulla) route for the DCML tract
Signal travels via afferent fibers through the dorsal root ganglion (DRG) into the spinal cord
Axons ascend ipsilaterally in the dorsal columns:
👉 Fasciculus gracilis (Lower limb & trunk)
👉 Fasciculus cuneatus (Upper limb & trunk)
Synapse occurs in the nucleus gracilis & nucleus cuneatus in the medulla
Explain the route Second-Order Neurons (Medulla ➔ Thalamus) for the DCML tract
Axons from the nucleus gracilis & nucleus cuneatus decussate (cross over) in the medulla
Travel through the medial lemniscus
Terminate in the ventral posterolateral (VPL) nucleus of the thalamus
Explain the Third-Order Neurons (Thalamus ➔ Somatosensory Cortex) route for th DCML tract
Neurons project from the VPL nucleus of the thalamus to the primary somatosensory cortex (Postcentral gyrus, Parietal lobe)
The brain interprets:
Type of sensory input
Intensity
Location
Explain the presentation of a Spinal Cord Lesion in the DCML tract
Ipsilateral loss of fine touch, vibration, and proprioception below the lesion
Example: Right-side lesion at T6 ➔ Sensory loss in right leg
Explain the presentation of Lesion in the DCML Above the Medulla
After Decussation (Above Medulla)
Contralateral loss of fine touch, vibration, and proprioception
Example: Left medial lemniscus lesion ➔ Sensory loss on the right side of the body
What is the spinocerebellar tract responsible for?
unconscious proprioception
coordination of movement
regulating muscle tone
Where does the spinocerebellar tract terminate?
Cerebellum
What would lesions in the spinocerebellar tracts cause?
ipsilateral coordination deficits but not sensory loss, unlike DCML and spinothalamaic lesions.
Can cause ataxia (uncoordinated limb movement)
Dysmetria (inability to control movement distance)
Intention tremor (during movement)
What is the function of the spinothalamic tract?
pain (nociception)
temperature sensation
crude touch and pressure (less precise than DCML pathway)
What happens in the spinothalamic tract at First-Order Neurons (Sensory Receptors ➔ Spinal Cord)
Detected by:
👉 Nociceptors: Detect pain
👉 Thermoreceptors: Detect temperature
👉 Mechanoreceptors: Detect crude touch
Pathway:
Signal travels via afferent fibers through the dorsal root ganglion (DRG)
Enters the spinal cord
Synapses immediately in the dorsal horn (substantia gelatinosa or nucleus proprius)
What happens in the spinothalamic tract at Second-Order Neurons (Spinal Cord ➔ Thalamus)
Decussation:
Axons cross over (decussate) immediately in the spinal cord (within 1-2 levels)
Pathways:
👉 Lateral Spinothalamic Tract: Transmits pain & temperature
👉 Anterior Spinothalamic Tract: Transmits crude touch & pressure
Destination:
Fibers project to the ventral posterolateral (VPL) nucleus of the thalamus
What happens in the spinothalamic tract Third-Order Neurons (Thalamus ➔ Somatosensory Cortex)
Thalamus Role:
VPL nucleus of the thalamus sends sensory information to the primary somatosensory cortex
Pathway:
Signal travels through the internal capsule
Interpretation:
The brain processes and localizes pain, temperature, crude touch, and pressure
Occurs in the parietal lobe (postcentral gyrus)