Anti-Inflammatory and Anti-Gout - Chapter 44

These flashcards cover key concepts related to anti-inflammatory and anti-gout medications, including mechanisms of action, side effects, and considerations for use.

Inflammation is a localized protective response stimulated by __ to tissues.

Injury

The five classic signs of inflammation include pain, fever, loss of function, __, and swelling.

Redness

The compounds involved in the inflammatory response include histamine, serotonin, bradykinin, __, and prostaglandins.

Leukotrienes

NSAIDs work by inhibiting the __ and COX-2 enzymes involved in the inflammatory process.

COX-1

One common complication of NSAIDs is __, which can lead to gastrointestinal upset.

GI upset and damage

Aspirin should not be given to children under 12 who have had a recent viral illness due to the risk of __.

Reye’s Syndrome

Ketorolac (Toradol) can be used for a maximum of __ days due to risk of complications.

5

Colchicine's mechanism of action is to reduce the __ response to urate crystals in joints.

Inflammatory

Probenecid increases the excretion of uric acid by inhibiting its __ in the kidneys.

Reabsorption

Allopurinol is primarily used for the prophylactic treatment of __ and to prevent tumor lysis syndrome.

Gout