Drugs that affect microtubules/actin

Colchicine

Targets MT; inhibits polymerization of tubulin to form microtubules by binding to the tubulin monomers. Promotes MT disassembly.

Vinblastin/Vincristine

Target MT; prevents the polymerization of MT protofilaments.

Compounds from periwinkle plant. Used in cancer treatment; disrupts mitotic spindle formation.

Antimitotic drugs

Interfere with spindle assembly and inhibit cell division. Useful for cancer treatment because they can target rapidly dividing cells, disrupting their ability to mitotically divide.

Taxol

Binds tightly to microtubules and stabilizes them, preventing their disassembly. This effectively disrupts the mitotic spindle and inhibits cell division.

Used in cancer treatment, especially breast cancer treatment