Citric Acid Cycle
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29 Terms
Enzyme that converts pyruvate → Acetyl-CoA
Pyruvate Dehydrogenase Complex
Enzyme that converts Acetyl-CoA and oxaloacetate to citrate
Citrate Synthase
Enzyme that converts citrate to isocitrate
Aconitase
What are/is the isomerization reaction(s) in the CAC?
conversion of citrate → isocitrate
Which reaction(s) in the CAC produce NADH?
isocitrate → a-KG, a-KG → succinyl-coA, L-malate → oxaloacetate
Which reaction(s) in the CAC produce QH2?
succinate → fumerate
Enzyme that converts isocitrate → a-KG
isocitrate dehydrogenase
Enzyme that converts a-KG → succinyl-coA
a-KG dehydrogenase complex
Enzyme that converts succinyl-coA → succinate
succinyl-CoA synthetase
Which reaction(s) in the CAC is ATP produced?
succinyl-CoA → succinate
Enzyme that converts succinate → fumerate
succinate dehydrogenase complex
Enzyme that converts fumerate → L-malate
fumerase
Enzyme that converts L-malate → oxaloacetate
malate dehydrogenase
How many ATP does oxidation of 1 acetyl-CoA molecule produce?
10
How many ATp does 1 QH2 molecule produce?
1.5
How many ATP does 1 NADH molecule produce through the glycerol-phosphate shuttle?
1.5
How many ATP does 1 NADH produce through the malate-aspartate shuttle?
2.5
Which reaction(s) in the CAC are oxidative decarboxylation reactions?
isocitrate → a-KG, a-KG → succinyl-CoA,
What kind of reaction is the conversion of fumerase → L-malate?
hydration
What kind of reaction is the conversion of acetyl-CoA → citrate?
condensation
What kind of reaction is the conversion of citrate → isocitrate?
isomerization
What kind of reaction is the conversion of isocitrate → a-KG??
oxidative decarboxylation
What kind of reaction is the conversion of a-KG → succinyl-CoA?
oxidative decarboxylation
What kind of reaction is the conversion of succinyl-CoA → succinate?
hydrolysis and substrate level phosphorylation
What kind of reaction is the conversion of succinate → fumerate?
oxidation
What kind of reaction is the conversion of fumerate → L-malate?
hydration
What kind of reaction is the conversion of L-malate → oxaloacetate?
oxidation
What is the rate limiting enzyme of the CAC?
isocitrate dehydrogenase
What is the rate limiting step of the CAC?
conversion of isocitrate → a-KG