Studied by 0 people
Looks like no one added any tags here yet for you.
Max Theiler
Development of yellow fever
vaccine
Daniel Bovet
Antihistamines
Frank Macfarlane, Burnet & Peter Medawar
Discovery of acquired
immunological tolerance
Rodney E. Porter & Gerald M. Edelman
Chemical structure of antibodies
Rosalyn R. Yalow
Development of radioimmunoassay
George Snell
Jean Dausset
Baruj Benacerraf
Major histocompatibility
complex
Harald zur Hausen
Role of HPV in causing
cervical cancer
Françoise Barré-Sinoussi
Luc Montagnier
Discovery of HIV
Jules Hoffman
Bruce Beutler
Discovery of activating principles of innate immunity
Ralph Steinman
Role of dendritic cells in adaptive immunity
James Allison and Tasuku Honjo
Discovery of cancer therapy by inhibition of
negative immune regulation
Niels Jerne
immunoregulation
Cesar Milstein
Georges E. Köhler
Technological advances in the development of
monoclonal antibodies
Susumu Tonegawa
Gene rearrangement in antibody production
E. Donnall Thomas
Joseph Murray
Transplantation immunology
Peter C. Doherty
Rolf M. Zinkernagel
Role of MHC in antigen recognition by T cells
Sydney Brenner
H. Robert Horvitz
J. E. Sulston
Genetic regulation of organ development and cell death (apoptosis)
Emil von Behring
Serum Antitoxins
Robert Koch
Cellular immunity to tuberculosis (Mycobacterium Tubercolosis)
Elie Metchnikoff
Role of phagocytosis
Paul Ehrlich
Role of antitoxins in immunity
Charles Richet
Anaphylaxis (came from the word aphylaxis)
Jules Bordet
Complement-mediated bacteriolysis
Karl Landsteiner
Discovery of human blood groups
Dausset and Rapaport
Histocompatibility antigens on leukocytes
Lindemann
1st to produce immune serum against tissue components
Metchnikoff and Besredka
prepared immune serum against leukocytes ( anti-leukocyte antiserum)
Bogomoletz
antisera against lymphoid tissues/ anti-lymphocyte antiserum
Haffkine
1st to perform cholera vaccination in India
Calmette and Guerin
Albert Calmette and Camillle Guerin were scientists and in 1923 they developed a vaccine against tuberculosis.
Lowenstein
tetanus toxoid - detoxified bacterial toxin
Glenny
diphtheria toxoid - detoxified bacterial toxin
Salk
Polio vaccine
Sabin
oral polio vaccine
Le Moignic and Pinoy
use of adjuvants in vaccines
Alouf, Chedid, Boquet
1st synthetic vaccine - diphtheria vaccine
Grubb
Idiotypes
Oudin
Allotypes
Waksman and Yankowic
role of thymus in immune system
Pfeiffer and Marx
Abs are developed in the spleen, bone
marrow, lymph nodes
Grabar and Williams
immunoglobulins are heterogeneous, detected the existence of IgA
nomenclature of Ig's was established and a.a. sequences of them were studied
Porter
2 Fab's and 1 Fc
Edelman
H chain and L chain
First complete a.a. sequence of an immunoglobulin
Putnam, Hilschmann and Craig
Constant and Variable region
Allison and Haskins
T-cell receptor
Coons
Immunofluorescence
Owen
Blood chimeras (in bovine twins)
Fagraeus
Abs are made in plasma cells
Svedberg
classify Ab through ultracentrifugation
Watson and Crick
Double helix of DNA
Jerne
Natural selection Theory
Talmage and Burnet
"Clonal Selection Theory"
Claman, et.al.
"B and T cell cooperation"
Prausnitz-Kustner
Passive transfer of allergic reactivity to an
allergen
Riley and West
role of histamine in inflammatory reactions
Burdet and Fenner
"Self-tolerance or immunologic tolerance"
Felton
Felton phenomenon (unresponsiveness or tolerance to pneumococcal polysaccharide)
Billingham, Brent, Medawar
Acquired immune tolerance in bone marrow chimeras in mice injected with allogeneic bone marrow at or before birth
Richet and Portier
Anaphylaxis
Arthus
Arthus phenomenon (a form of immediate hypersensitivity observed in rabbits after injection of antigen to which the animal has already been sensitized and has specific IgG antibodies.)
Shwartzman
Shwartzman phenomenon (rare reaction of a body to particular types of toxins, called endotoxins, which cause thrombosis in the affected tissue.)
Landsteiner
Father of Immunohematology
Haptens
Bordet and Gengou
Complement Fixation Test
Breinl and Haurowitz
Templates theory
Tiselius and Kabat
Antibodies are immunoglobulins
Pauling
"Variable Folding Theory of Antibody
Formation"
Bordet
Isoantibody
Wassermann and von Dugern
"Anamnesis"
Hypersensitivity Studies
bad side of the immune response
Hypersensitivity Studies
bad side of the immune response
Wright and Douglas
Opsonin (foreign microorganisms or cells making them more susceptible to phagocytosis.)
Paul Ehrlich
Ehrlich's Side Chain Theory
First to explain the appearance of
antibodies in the circulation
Key and lock
Bordet
Should have physical apperance or characteristics (Ehrlich's Side Chain Theory)
Arrhenius and Madsen
It should be reversible (Ehrlich's Side Chain Theory)
Fodor
action of an immune serum on microbes
Emil von Behring and Kitasato
neutralizing antitoxic activity of sera
Calmette
similar neutralizing activity against snake
venom
Pfeiffer and Issaef
Pfeiffer phenomenon (vibrio cholerae is introduced to an immunized guinea pig where it destroys cholera)
Jules Bordet
reconciled humoral and cellular theories
"Sensitizer" and "Alexine" (Complement)
Elie Metchnikoff
Discovered the role of leukocytes in phagocytosis
Celsus
Inflammation in animals
Virchow
All cells come from pre-existing cells
Inflammation Changes occur in CT
Arnold and Cohnheim
Inflammation in local vascular lesion
Girolamo Fracastoro
contgion
Edward Jenner
Smallpox vaccine
Louis Pasteur
Reduced the effect of chicken cholera, anthrax and
rabies vaccines development
Coined the term vaccine (from the Latin
vacca, meaning "cow")
Richet and Hericourt
blood immunized with staphylococci (weak
strains) gives partial protection to the same
organism
Charrin and Rodger
serum of animal immunized with
Pseudomonas aeruginosa agglutinated a
suspension of the same microbes
Pfeiffer
Specificity of the Protective Effects of
Immunization
China & Lady Montagu of Turkey
Variolation
Mithridates
Mithridatism (inducing poison to tolerate toxic)
Central Africa
Venom and ant eggs as treatment for
snake bites
Dutch Guiana
"Djoekas" Venom and ant eggs as treatment for
snake bites
