section 9 - microfilaments (actin filaments)
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17 Terms
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stress fibres
in stationary cell
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cortical actin
dividing
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contractile ring
in ring
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actin fibres
migratory cell
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where actin filaments concentrated
actin bundles in microvilli
ring of actin fibres between adherens junctions
actin fibres at cell cortex
ring of actin fibres between adherens junctions
actin fibres at cell cortex
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actin filaments depolymerised by
cytochalasin
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actin filaments stabilised by
phalloidin
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actin microfilaments in evolution
highly conserved
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actin microfilaments as a dynamic polymer
G-actin monomers, F-actin fibres
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master organiser for actin microfilaments
none
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microfilaments role
dual role in eukaryote cells in conjunction with actin binding proteins
* structural
* force generation
* structural
* force generation
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structural role of microfilaments
responsible for cytoplasmic viscosity - rapid response to cell signals, local or global
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force generation of microfilaments
polymerisation
contraction
vectoral transport
cell motility
contraction
vectoral transport
cell motility
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treadmilling of actin polymer
more growth on one end of polymer - actin moves along filament - ATP dependent process (monomers lost)
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G-actin
ATPase
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villin
in brush border, actin filaments are cross linked by villin
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Gelsolin/villin superfamily
each 6 domains
without extra domain attached to 6, actin severing protein
with extra domain attached to 6, actin bundling protein
without extra domain attached to 6, actin severing protein
with extra domain attached to 6, actin bundling protein
Note 
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