Coagulation Factors

common name for factor I

fibrinogen

role of factor I

acts as a substrate and is the fibrin precursor

where is Factor I synthesized?

plasma and platelets

what is the common name for FII?

prothrombin

role of factor II

serine protease, thrombin precursor

helps with pro and anticoagulation

common name for Factor III

tissue factor

role of factor III

cofactor in extrinsic xase

where is factor III synthesized?

the membrane of nonvascular cells

common name for FIV

calcium

role of factor IV

cofactor in some coag reactions

where is factor IV synthesized?

outside sources

common name for factor V

proaccelerin

role of FV

cofactor in prothrombanse complex

common name for FVII

proconvertin

role of FVII

serine protease; part of extrinsic xase

common name for FVIII

antihemophilic factor

role of FVIII

cofactor in intrinsic xase; complexed with VWF

where is FVIII made?

liver and endothelial cells

role of VWF

von willebrand factor

platelet adhesion, stabilized FVIII in circulation 

where is VWF made?

endothelial cells and megakaryocytes

common name for IX

plasma thromboplastin or christmas factor

role of FIX

serine protease; intrinsic xase component

common name for FX

stuart factor

role of FX

serine protease; prothrombinase complex 

where intrinsic and extrinsic converge into common

common name for XI

plasma thromboplastin antecedent

role of FXI

serine protease; contact factor (XI)

common name for FXII

hageman factor

role of FXII

serine protease; contact factor (XII)

common name for FXIII

fibrin stabilizing factor

rple of FXIII

transglutaminase; fibrin stabilizer

wher eis FXIII made

liver, megakaryocytes, monocytes, macrophages

common name for HK

fitzgerald factor

role of HK

cofactor; contact factor; complexes with PK and FXI

common name for PK

fletcher factor

role of PK

serine protease complexed with HK; contact factor