Pharmacokinetics in Pregnanacy and Lactation

LO: Describe the physiological changes in pregnancy and the impact on ADME

LO: Understand how to predict infant drug exposure from breast milk

LO: Understand the underlying differences in PK during pregnancy and lactation

Does the PK equations for pregnant women change compared to normal people?

No, they are all the same. The only change is physiological changes.

The pharmacokinetic equations relate to the calculations of drug absorption, distribution, metabolism, and excretion (ADME) in individuals, considering factors like volume of distribution, clearance, and half-life.

What are the physiological changes during pregnancy in regards to ADME?

Describe hepatic clearance in pregnancy?

Describe the differences in high and low extraction ration for pregnancy?

High extraction ratio drugs are cleared more efficiently during pregnancy due to increased hepatic blood flow, while low extraction ratio drugs may show less change in clearance. This affects the overall drug metabolism and dosing during pregnancy.

Explain drug metabolism in pregnancy and its clinical consequences

Describe renal clearance in pregnancy?

Describe placental drug transport in pregnancy?

Describe fetal pharmacokinetics

Describes PK during lactation

Explain the milk plasma ratio and RID