Main Drugs Pharmacology Overview

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29 Terms

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ACE Inhibitors

Inhibit the enzyme ACE, which converts angiotensin I to angiotensin II, leading to vasodilation, reduced blood pressure, and decreased aldosterone. Side Effects: Dry cough.

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Beta Blockers

Block β-adrenergic receptors (mostly β1 in the heart), leading to decreased heart rate, reduced myocardial contractility, and lowered blood pressure. Side Effects: Bradycardia (slow HR).

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Calcium Channel Blockers

Inhibit L-type calcium channels in vascular smooth muscle and/or cardiac muscle, causing vasodilation and potentially reducing heart rate and contractility. Side Effects: Constipation.

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Angiotensin II Receptor Blockers (ARBs)

Block angiotensin II from binding to AT1 receptors, causing vasodilation and reduced aldosterone secretion. Side Effects: Headache.

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Opioids

Bind to mu (μ), kappa (κ), and delta (δ) opioid receptors in the CNS and PNS, inhibiting ascending pain pathways and altering pain perception. Side Effects: Respiratory Depression.

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Barbiturates

Enhance GABA-A receptor activity by prolonging the duration of chloride channel opening, leading to CNS depression. Side Effects: Sedation.

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Benzodiazepines

Enhance GABA-A receptor activity by increasing the frequency of chloride channel opening, causing anxiolysis, sedation, and muscle relaxation. Side Effects: Sedation.

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Statins

Inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, lowering LDL cholesterol by upregulating LDL receptors in the liver. Side Effects: GI Issues, Rash.

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Triptans

Stimulate 5-HT receptors in cerebral arteries, causing vasoconstriction and reducing headache symptoms. Side Effects: Vasoconstriction.

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 Anticholinergic drugs (ACh blockers/Acetylcholine blockers)

Block acetylcholine (ACh) receptors in the vestibular nuclei (located deep in the brain)/the labyrinth (inner ear) and reticular formation. Side Effects: Dizziness, erythema.

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Antihistamines (H1 receptor blockers)

Block H1 receptors, thereby preventing ACh from binding to receptors in the vestibular nuclei. Side Effects: Dizziness, sedation.

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Antidote for Heparin

Protamine sulphate can be given as an antidote in case of excessive anticoagulation.

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Antidote for Warfarin

Antidote is vitamin K.

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Digoxin

A cardiac glycoside derived from the Digitalis plant, increases myocardial contractility by inhibiting the Na+/K+-ATPase pump.

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Digoxin Mechanism of Action

Increases myocardial contractility and alters electrical conduction in the heart, decreasing conduction rate and prolonging the refractory period.

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Narrow Therapeutic Window (Digoxin)

Requires drug level monitoring (0.8-2 ng/mL) due to risk of toxicity, especially with hypokalemia.

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Heart Failure (Left-sided)

Characterized by pulmonary edema, coughing, shortness of breath, and dyspnea.

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Heart Failure (Right-sided)

Characterized by systemic venous congestion, pedal edema, jugular venous distension, ascites, and hepatic congestion.

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Treatment for Status Epilepticus

Diazepam (Valium) is for immediate treatment.

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Common ending for ACE Inhibitors

pril

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Common ending for Beta Blockers

lol

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Common ending for Calcium Channel Blockers

pine, mil, zem

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Common ending for Angiotensin II Receptor Blockers (ARBs)

sartan

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Common ending for Barbiturates

tal

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Common ending for Benzodiazepines

pam

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Common ending for Statins

statin

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Common ending for Triptans

tans

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Common ending for Anticholinergic drugs (ACh blockers/Acetylcholine blockers)

ine

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Common ending for Antihistamines (H1 receptor blockers)

ate, ine