mistake molecules and cells flashcards

which laminin isoforms for CMD and JEB

• CMD - laminin 2 - 221

• JEB - laminin 5 - 332

adhesion cascade

• rolling

• bind to p selectin on endothelium

• activated integrins through chemokines MCP-1

• squeezed between the gaps of the endothelial cells with PECAM-1

example of pattern recognition receptor

• TLR

• recognises PAMPs and DAMPs

example of nsaid and mechanism

• dexamethasone

• cox2/1 enzyme inhibitor

• decreases prostaglandin pge2 and pgi2

• decreases fever and pain

ras mutation which uncouples it from growth factor signalling

• mutations at glycine 12

• impair intrinisc gtpase activity

• no GAP hydrolysis of GTP

• permanently activated Ras

PKM in cancer cells

• PKM2>PKM1

• decreased catalytic activity

• more time for intermediates to be used in biosynthetic pathways

integrin for cmd and jeb

• cmd - alpha 7 beta 1

• jeb - alpha 6 beta 4

mtp

• inner membrane

• depends on channels opening

• leads to necrosis

mutations which lead to sufficiency in growth factor signalling

• mutation to Ras - always GTP bound, does not require RTK signalling

• mutation to PTEN - increases PI3K and Akt

• mutation to RTK - independent phosphorylation without ligand