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What are the 3 time scales of Brain Plasticity?
Evolutionary time (review of the remarkable changes over a relatively short period of time)
Developmental changes (within a lifetime)
Experiential changes (moment to moment)
What kind of genes contribute to larger brain size for humans?
Genes that play a role in generating neurons, and our Notch2NL genes
What are Notch2NL genes?
They help create cells that later become neurons, and the tissue triples in size when combined with isolated brain tissue
What are the 5 differences between non-human primates and humans?
- Absolute and relative brain size
- Changes in shape (prefrontal cortex and cerebellum)
- Our neurons have more dendrites and longer axons
- "Novel" structures in the parietal region of the brain involved in complicated thinking and movement.
- Genes that increase number of neurons in brain tissue and slow brain development
What are some theories that environmental pressures favor brains with more neuronal interconnections?
1. Climate change = drier landscape and primates came down from trees, started walking upright and vision became more important
2. tools and hunting, which required more brain power and planning, etc.
3. Cooking-- required more brain power, and also increased calories/energy for neurons
What is gray matter?
areas of the nervous system with a high densityof cell bodies and dendrites, few myelinated axons, e.g.cortex
What is white matter?
areas of the nervous system containing mostly myelinated axons (e.g., corpus callosum)
What does white matter do?
carry signals from one part of the CNS to another
what does grey matter do?
Processes and regulates information in the CNS
What did the longitudinal MRI study on white matter show?
measured the density of white matter in the brain, showed that percent of white matter in brain increases with age
What did the morphometric study of human cerebral cortex development on gray matter show?
- a study of density of gray matter at different ages.
- focused on visual cortex
The developmental trajectory of changes in gray matter will:
will increase to about age 1 then steadily decrease
Assume different brain regions have different gray matter density trajectories. How should they be ordered?
What improves as gray matter decreases?
Cognitive function improves because unused connections are pruned away, and the remaining connections get more use/get stronger
Increase in density of white matter continues into...
3rd decade of life
post-natal white matter/grey matter development age range:
initial increase and then a decrease
when do the sensory areas (occipital lope) change?
early on
when do the prefrontal cortex and decision making change?
later on
Which idea is consistent with the idea that experience plays a role in gray matter pruning:
the blindfolded kitten experiment
What increases risk for schizophrenia?
too much pruning
What increases risk for autism?
Too little pruning
What does the London taxi cab experiment show?
The percentage of grey matter in the hippocampus grow and the size of the hippocampus grows
what is classical conditioning?
learning associations and generalization of reflexes to new stimuli
what is Operant/Reward based learning?
How consequences (rewards/punishment) shape behavior
Who was pavlov?
Nobel prize winning physiologist established procedures for studying digestion in living animals.
What is Pavlov's experiment?
He was interested in the way behavior is conditioned by a stimulus. Therefore, he conducted an experiment where he made a dog salivate to the sound of the bell rather than food.
US =
UR =
CS =
CR =
unconditioned stimulus
unconditioned response
conditioned stimulus
conditioned response
What are the classical conditioning basics as understood by Pavlov:
The CR is very much like the UR
But as a function of experience it is triggered by the CS that was paired with the US
This can be adaptive (but not necessarily)
why has classical conditioning attracted interest?
A simple but powerful way to adapt to a complex world, highly general across species
What are the necessary & sufficient conditions for learning?
- Pairings
- backwards conditioning doesn't work
what's the relationship between pairings and conditioned responses?
The more often the pairing occurs, the stronger the conditioned response
Early pairings have more effect than later pairings
Why do we obey the law?
(1) The feelings of guilt and virtue motivate us to obey the law and resist temptation
2) establishing emotional responses to new stimuli
The necessary and sufficient conditions to establish classical conditioning (learned associations):
Role of expectations
what are phobias?
irrational fear of a specific object or situation
what percent of the population is impacted by phobias?
2-8% population
what's the Little Hans case?
Hans was a five-year-old who developed a phobia of horses after seeing one fall down and die.
Freudian Interpretation of phobias
people have unconscious impulses or thoughts that cause conflict between the three parts of the human personality or psyche: the id, superego, and ego.
Can we find everyday (outside of the lab) evidence of role of conditioning in phobias?
Yes, the defibrillator study.... 72 patients with implantable cardio/defibrillators, many patients can anticipate arrhythmias thus anticipate shock.... 16% developed anxiety disorders, including phobias, over a 6 year period
According to CC, how do you extinguish a conditioned response?
Present the CS without the US
Arachnophobia experiment:
from pictures of spiders to handling a real spider in a group setting (exposure, "extinction" & relaxation )
Stimulus hierarchy
Teach relaxation (that competes with fear)
Observations that do not fit classical conditioning account of phobias
traumatic events typically do not result in phobias
Phobias but no known trauma
Some stimuli are much more likely to be the focus of phobias than others
Anxiety disorders: Heritability studies
11% if no disorders in parents,
25% if one parent suffers from anxiety, and
40% of both parents suffer from anxiety.
Monkey Snake experiment
many lab-reared monkeys are not ostensibly afraid of snakes; wild reared monkeys are always very afraid.... when scared monkeys, watched brave monkeys, they became less afraid
How to explain what does not fit CC account?
- Imitation learning
- Inference
- Genetic differences in susceptibility to stressors
how to explain success of classical conditioning based treatment and apparent causal discrepancies
inference and imitation (observation/empathy) trigger internal conditioning trials
How to "face your fears"?
Treatments based on conditioning are effective and produce biological as well as behavioral changes.
Hang out with good role models (e.g., "brave monkeys")
What did Pavlov achieve
revealed that conditioned behavior was highly orderly: Strength of conditioning varied systematically as function of UCS properties, CS properties, and timing of presentation of stimuli
Who was Skinner?
behaviorist who developed the origins of voluntary behavior (shaping) and
it's persistence and pattern (schedules of reinforcement)
What is operant conditioning?
the learning of voluntary behavior through the effects of pleasant and unpleasant consequences to responses
What was the origin of reinforced behavior?
- Spontaneous actions
- Shaping
- This is reminiscent of Darwin
what is shaping in operant conditioning?
rewards and punishments select certain actions, thereby producing new topographies
Why does persistence, frequency and timing of reinforced behavior matter?
History of reinforcement ("schedules of reinforcement") determines topography of voluntary actions, when they occur, and their frequency
discriminative stimulus
an event that sets the occasion for a reinforcement contingency to be in effect
Operant Behavior
any pattern of behavior that yields a particular reinforcer. An operant is a means to an end, rather than a specific response.
Reinforcer
Any event that increases the frequency of preceding activities
Schedule of reinforcement (contingency of reinforcement):
A rule that specifies the relationship between voluntary action and its consequences (like a contract):
Examples of schedules of reinforcement
- every 10 lever presses yields a reward
- after a delay of 30 seconds from the last reward, the next response will produce a reward.
How to measure patterns of behavior
- the "cumulative recorder"
Why is there a pause in responding after a reward on fixed ratio and fixed interval schedules?
different histories of reinforcement (schedules) should yield
different cumulative recorder patterns...
Notice that the reinforcer in operant conditioning can be the same as the US in classical conditioning. Is it also true that ?
In operant conditioning the subject's behavior determines whether the reward (US) is delivered
What are some reinforcement that applies to gymnasts?
what their coaches think, or social reinforcers
the dictator game
A mutually anonymous behavioral economics game in which one person ("the dictator") unilaterally determines how to split an amount of money with the second player.
in operant conditioning new behaviors emerge as __________________________ and ------------------------
the result of more or less random movements;
an environment or experimenter that rewards a subset of the randomvariations
In the article titled: "What happens when contingency treatment ends?" The intervention involved ___________. The basic finding was
a chance to win prizes; neither client resumed regular drug use
The logic of reinforced learning is the same as the logic of
natural selection
compulsion
an irresistible urge to behave in a way that is incompatible with one's conscious wishes
Why is self-control important?
self control predicts good health, higher income, and better school performance.
What's the rule regarding time and rewards
you always choose the reward with highest value
skinner argues that _____ of behavior are based on ________
conventional explanations; internal states
__________ are also a function of their history of reinforcement
internal events
psychology should focus on.....
tangible histories of reinforcement and patterns of overt behavior