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px — stage 2 of iron deficiency, before frank anemia develops
results for CBC & iron studies for 28 year old woman
CBC — all results within reference intervals
RDW — 15%
serum iron — decreased
TIBC — increased
% transferrin saturation — decreased
serum ferritin — decreased
what can you conclude?
anemia of inflammation
a bone marrow biopsy was performed as part of the cancer staging protocol for a px with HODGKIN LYMPHOMA.
no evidence of tumor spread was apparent in bone marrow.
abnormal findings:
M:E ratio — slightly elevated
WBC count & RBC morphology — appeared normal
prussian blue stain — abundant stainable iron in marrow macrophages
CBC Hgb — 10.8 g/dL
RBC indices — within reference intervals
RBC morphology — unremarkable
these findings are consistent with?
serum iron level — decreased
TIBC — decreased
% transferrin saturation — normal
serum ferritin level — normal
what is the iron study results for the px with HODGKIN LYMPHOMA?
serum lead level
35 year old woman
symptoms — headaches, dizziness, nausea
headaches have been increasing in severity over the past 6 months — coincident with her move into older house (built in 1900); she has been renovating the house (stripping paint from woodwork)
CBC results
mild microcytic hypochromic anemia
polychromasia
basophilic stippling
which tests would be most useful in conferming the cause of her anemia?
chronic gastrointestinal bleeding
in men & postmenopausal women whose diets are adequate, IDA most often results from?
15 year old boy who eats mainly junk food
individual that is at greatest risk for development of IDA
30 year old man with severe RA
individual at greatest risk for development of anemia of inflammation
any condition that prevents iron incorporation into protoporphyrin IX
in what situation will increased levels of free erythrocyte protoporphyrin be present?
increase during inflammation & reduced iron absorption from erythrocytes
hepcidin levels in pathogenesis of anemia of inflammation
impairments to the use of iron within mitochondria
sideroblastic anemias result from
hepcidin-ferroportin iron regulatory system
generally, most instances of hereditary hemochromatosis results from mutations that impair __
heightened propensity for sunburn
in erythropoietic porphyrias, mild anemia may be accompanied by what distinctive clinical finding?
equivocal for iron deficiency
px — developing iron deficiency from chronic intestinal bleeding caused by aspirin use for RA
how would these results be interpreted?
soluble transferrin receptor
for px with screening iron study values that are equivocal for iron deficiency, which test would be most helpful in determining whether iron deficiency is present or not?