Secretory Pathways and Exocytosis

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15 Terms

1

three ways to leave trans-golgi

  1. endo-lysosomal pathway

  2. regulated secretory pathway

  3. constitutive secretory pathway

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2

- proteins are sorted into the endo-lysosomal pathway

M6P-tagged

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3

in the regulated secretory pathway, a small group or single type of small molecules or proteins - to form dense granules that are packaged into -

aggregate, secretory vesicles

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4

proteins that lack - (two things) or fail to - default to the constitutive secretory,

M6P tag, ER retrieval signals, aggregate into secretory vesicles

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5

secretory vesicles are destined for the - and -

plasma membrane, exocytosis

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6

all cells use the constitutive secretory pathway to - or - the plasma membrane with new - and -

replenish, load, lipids, membrane proteins

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7

constitutive secretory vesicles bud from the - and proceed to the -

trans-golgi, PM

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8

specialized cells bud - carrying large amounts of - cargo

regulated secretory vesicles, concentrated

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9

soluble cargo is only one or few types of small molecules or proteins which aggregate into - and segregate into regulated secretory vesicles

dense granules

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10
<p>immature secretory vesicles bud-off - retrieval vesicles that recycle membrane proteins back to the -, reducing vesicle - and - cargo in the mature secretory vesicle</p>

immature secretory vesicles bud-off - retrieval vesicles that recycle membrane proteins back to the -, reducing vesicle - and - cargo in the mature secretory vesicle

clathrin coated, trans golgi, size, concentrating

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11

pancreatic beta cells form regulated secretory vesicles that are highly concentrated with - cargo

insulin

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12

How are insulin secretory vesicles regulated by glucose concentration?

  1. blood [glucose] rises → glucose transport - (into/out of) beta cells → increase in [-]

  2. high [ATP] closes - channels → accumulation of - → membrane - (depolarization/repolarization)

  3. voltage-gated Ca2+ channels in PM - (open/close) → Ca2+ - (enter/exit) → Ca2+ primes -

  4. secretory vesicles and PM fuse → -

into, ATP, ligand gated K+, K+, depolarization, open, enter, v-snares, insulin released

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13

polarized cells direct exocytic vesicles to the - domain

appropriate plasma membrane

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14

most epithelial cells in tissues are polarized and have two or more - or -

distinct membrane faces - domains

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15

domains perform specialized functions and are thus composed of different types of - and -

membrane proteins, lipids

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