Coagulation Factors

I

Fibrinogen

II

Prothrombin

III

Tissue Factor

IV

Ionic Calcium

V

Labile Factor

VII

Stable Factor

VIII

Antihemophilic factor

VWF

von Willebrand factor

IX

Christmas Factor

X

Stuart-Prower factor

XI

Plasma thromboplastin antecedent (PTA)

XII

Hageman factor

XIII

Fibrin-stabilizer factor (FSF)

Prekallikrein

Fletcher factor, pre-K

High-molecular-weight kininogen

Fitzgerald factor, HMWK

What is the function of fibrinogen (factor I)

• hydrolyzed by thrombin the forms primary structural protein of fibrin clot

• binds to gpIIb/IIIa on platelet membrane

• also found in platelet alpha granules

What is the function of prothrombin (factor II)

• most abundant vit K factor

• converted to thrombin via factor Xa, Factor Va, PF3 and calcium

What is the function of thromboplastin (factor III)

• involved in extrinsic pathway of coagulation

• activates factor VII with help of calcium

• cofactor

What is the function of calcium (Factor IV)

• plays a role in all pathways

• needed for aggregation involving fibrinogen

What is the function of Labile Factor (Factor V)

• cofactor

• seen in alpha granules of platelets

• member of prothrombinase complex

What is the function of Proconvertin (stable factor) (factor VII)

• extrinsic pathway

• vitamine K dependent

• activated by TF and calcium

What is the function of Antihemophilic Factor (factor VIII)

• intrinsic pathway of coagulation

• cofactor

• cleaved by thrombin

• combines with factor IX, calcium, and PF3 to activate factor X

What is the function of Christmas factor (factor IX)

• vitamin K dependent factor

• participates in intrinsic pathway thru activation by factor XIa and calcium

• also activated by factor VIIa in the extrinsic pathway

What is the function of Stuart-Prower (factor X)

• vitamin K dependent

• activated by tenase complex

• activated at end of intrinsic and extrinsic process

What is the function of plasma thromboplastin antecedent (factor XI)

• participates in the intrinsic pathway

• activated by factor XIIa and HMWK

What is the function of Hageman Factor (factor XII)

• intrinsic pathway

• in vivo, collagen can activate it which then activates factor XI, prekallikrein, and HMWK

• can convert plasminogen into plasmin

What is the function of fibrin stabilizing factor (factor XIII)

• formation of stable fibrin clot