Extracellular Matrix Components

Structural Proteins

Support shape and organization of cells

Proteoglycans

Protein core with negatively charged sugars/carbohydrates attached. Called GAGs

Collagen

Provides strength to connective tissue within the ECM. Most abundant protein by weight in human body. A fibrulous protein 

Fibroblasts

Main cell in the ECM, makes collagen in small units inside cell. Collagen then rearranges itself in the matrix.

Fibronectin

Helps hold ECM together, a type of structural protein. Also binds collagen to other cells, a type of glue in the ECM that has alot of binding sites

Laminin

Another glue type protein found in the ECM. Binding sites that helps attach proteins or cels together within the matrix

Elastin

Provides resistance and an elastic like texture for protection within the ECM. Why skin reacts when you pull on it. It is a stretchy molecule. 

Hyaluronic Acid

Substrate that binds proteoglycans together

Integrins

A transmembrane protein found in the membrane of a cell. These proteins connect to things like collagen or fibronectin to hold stability within the matrix

Connective Tissue 

Tissue that makes up the ECM