Chapter 5: DNA Replication, Repair, and Recombination

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Mobile genetic elements

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16 Terms

1

Mobile genetic elements

________ include transposons, which move within a single cell (and its descendants), plus those viruses whose genomes can integrate into the genomes of their host cells.

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2

DNA Replication

The biological process of producing two identical replicas of DNA from the original DNA molecule.

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3

Mutation

A permanent change in the DNA that occurs when the cell's DNA maintenance fails.

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4

Low mutation rates

Mutation rates that are necessary for life, as an increase in mutation frequency can lead to the incidence of cancer.

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5

DNA polymerase

Enzyme responsible for the formation of new DNA chains during DNA replication.

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6

Watson and Crick

Scientists who proposed the double helical structure for DNA and the semi-conservative DNA replication scheme.

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7

Semi-conservative DNA replication

The proposed scheme for DNA replication where the two strands of DNA separate and act as a template for the synthesis of new complementary strands.

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8

Unwinding of the DNA

The process of separating the two strands of DNA during DNA replication.

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9

Helicase

Enzyme responsible for unwinding the DNA during DNA replication.

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10

DNA Repair

The set of processes that corrects spontaneous changes in DNA to maintain its integrity.

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11

Homologous recombination

The exchange of DNA strands between homologous chromosomes during genetic recombination.

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12

DNA Base-pairing

The process of re-forming the DNA double helix from its separated single strands during homologous recombination.

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13

Transposition

The movement of genetic elements within a genome by either retrotransposition or DNA transposition.

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14

Conservative site-specific recombination

The rearrangement or exchange of DNA segments between specific target sites in the genome without movement to a new genomic location.

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15

DNA Repair Mechanisms

The various processes involved in correcting errors and damages in DNA sequences, including mismatch repair, base excision repair, nucleotide excision repair, double-strand break repair, and homologous recombination.

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16

Epigenetic Modifications

Chemical changes to DNA or associated proteins that affect gene expression without altering the underlying DNA sequence.

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