Pharmacology of Renal System
5.0(1)
Studied by 6 people5.0(1)
Call Kai
Learn
Practice Test
Spaced Repetition
Match
Flashcards
Knowt PlayCard Sorting
1/30
Earn XP
Description and Tags
Study Analytics
Name | Mastery | Learn | Test | Matching | Spaced |
|---|
No study sessions yet.
31 Terms
1
New cards
osmotic diuretics moa
on proximal tubule, increases urinary excretion of almost all electrolytes
2
New cards
Cli osmotic diuretics
narrow → acute RF, brain + eye edema
3
New cards
Mannitol
osmotic diuretic
4
New cards
SE osmotic diuretics
hyponatremia + pul edema OR hypernatremia + dehydration
5
New cards
furosemide
loop diuretic
6
New cards
what is the strongest diuretic?
loop diuretics (furosemide)
7
New cards
Moa loop diuretics
on loop of henle → blocks reabsorption Na + K + H20, Mg + Ca excreted, increases renal flow + venodilation
8
New cards
Cli loop diuretics
emergency, HTN + edema in RF, pul edema in HF
9
New cards
loop diuretics are used w/
K+ sparing diuretics
10
New cards
SE loop diuretics
cramps, ion imbalances (hypokalemia, hypomagnesemia, hyperuricemia), hypotension, ototoxicity
11
New cards
DDI loop diuretics
aminoglycosides, lithium, digoxin, ACE-i
12
New cards
hydrochlorothiazide (HCht) + Indapamide
thiazide diuretics
13
New cards
Moa thiazides
on distal tubule → increases salt + water loss
14
New cards
Cli thiazides
wide → HTN, HF (arrhythmias, post-MI), diabetes insipidus
15
New cards
SE thiazides
hypercalcemia, gout, dizziness, cramps, hypokalemia
16
New cards
DDI thiazides
lithium, digoxin, ACE-i
17
New cards
SE of thiazides are hypokalemia which is remedied by administering what
K+ sparing diuretics
18
New cards
Amiloride
K+ sparing diuretics (weak)
19
New cards
moa k+ sparing diuretics
on distal tubule
20
New cards
K+ sparing diuretics SE
hyperkalemia, GIT symptoms
21
New cards
moa spironolactone
ALD regulated → resembles steroid, antagonist mineralocorticoid r in distal tubules + collecting duct, natriuretic + k+ sparing
22
New cards
SE spirinolactone
hyperkalemia, mimics steroids (gynecomastia, impotence, menstrual disturbances)
23
New cards
Cli spirinolactone
cardiac edema + HTN, cirrhosis
24
New cards
Th urge incontinence (overactivity detrusor)
parasympatholytics (oxybutinin) + alpha-agonist
25
New cards
moa psly (oxybutinin)
inhibition detrusor contractions, extends time of urgency to urinate
26
New cards
moa alpha-agonists
increases intraurethral p → increased sphincter tone → bladder closure
27
New cards
th for stress incontinence (defective closure)
a-agonists
28
New cards
most common cause of drug induced incontinence
diuretics, alcohol, anticholinergics
29
New cards
Th BPH
a1-antagonists (tamsulosin) + 5a-reductase i (finasteride)
30
New cards
moa a1 antagonist
causes m in prostate to relax
31
New cards
5a-reductase i (finasteride) moa
competes w/ testosterone for enzyme (DHT inhibited) → prostate volume reduction
Note 
Flashcards (92)