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Environmental causes of cancer
UV Radiation
Air Pollution
Smoking - affect chromosome integrity
How many Cancers are caused by viruses
15%
Cancer and food
Affects well-being, overall health, ability to recover
Age and Genetic cancer factors
77% of all cancers occur above or around 55 yrs, and DNA damage over time leads to cancers
Breast Cancer Genes
-BRCA1 and BRCA 2 which are tumor suppressor genes, mutate to cause breast and ovarian cancer
Tobacco carcinogens
carcinogens are Polycyclic Aromatic Hydrocarbons, or organic compounds containing only H and C, ex. benzene.
small amounts in leaves, effect occurs over repeated exposure
Taxol in plant properties
Extracted form bark
Inhibits growth of parasitic fungi in soil
used by tribes for things like pain and blood purifier, etc.
Taxol plant
western/pacific yew
flat needle like leaves
cone with 1 black seed and red “aril”
Taxol use
- Stops malignant tumor growth \n - Helpful in advanced cases of ovarian & breast cancer \n - Used today in ever-evolving drug combinations
Taxol mechanism of action
inhibits tubulin (spindle) separation (binds to B-tubulin subunit of micotubules)
Microtubules do not disassemble after cell division
causes unequal cell divisions
no future cell division, apoptosis
Taxol problems
large quantities of bark needed, 2g to treat patient
1g of taxol obtained from 3 trees
slow growing tree
rare in northwestern pacific
Initially lab synthesis too complicated
Solution: look for taxol in similar species
Mexican Yew
Produced 10x more taxol than pacific yew
English Yew
needles contain abundant amounts of taxol precursor baccatin
Baccatin modified to produce
Taxotere/docetaxel
Twice as effective in prevention breakdown of mitotic spindle
Being tested on skin, bladder, lung, cervical, ovarian cancer
Enophytic fungi
Also produce taxol, even after removal from host
can be lab grown
inexpensive and quick way to produce taxol
Taxol now
Purely synthesized in lab
All taxol produced in germany by Python Biotech via plant cell fermentation
Turmeric active compound
Curcumin
Curcumin properties
-Antioxidant - Free radical scavenger \n Anti-amyloid - - May inhibit accumulation of amyloid in brains of
Alzheimer’s patients, break up existing plaques
Anti-inflammatory - - Inhibits enzymes involved in inflammation
Anti-tumor - - Many ongoing studies
Curcumin and antioxidant activity
inhibits oxidation of lipid membrane and DNA
Reduces DNA damage and oncogene formation
Curcumin and anti-angiogenesis
prevention of new blood vessel growth
Blocks enzymes that enable tumors to create own blood supply
Iron, copper needed by these enzymes
Curcumin and oncogene expression
interference with oncogene expression
Blocks cytokines that activate transcription growth factors, which are overexpressed in cancer cells.
Induces apoptosis in cancerous cells interruption at G2 stage
Curcumin problems
low water solubility
quickly metabolizes
inefficiently absorbed
degrades p53- which removes damaged cells likely to become tumors (may accelerate tumor development)
Mayapple plant
toxic
death in high consumption doses
Leaves, roots and unripe fruit are toxic
ripe fruit is edible
Mayapple compounds
Etoposide
Teniposide
Podophyllotoxin
Etoposide and Teniposide Mechanism of Action
Act on DNA replication
Cause DNA breakage and errors
Reduce growth and expansion of cancers
Prevents topoisomerase II from uncoiling DNA
Results in DNA breakage and apoptosis
Mayapple administration
IV
Injection
Oral Tablet
Mayapple side effects
Bone marrow suppression (decrease in WBC and RBC)
Dizziness
Nausea
Bleeding (platelet suppression)
Hair loss
Periwinkle
Native to Madagascar
Apocynaceae
Active compounds of Periwinkle
Vincristine
Vinblastine
Vinblastine and Vincristine
80% remission in Hodgkins
99% in acute lymphocytic leukemia
Vincristine and Vinblastine mode of action
bind to tubulin dimers and disrupt microtubule structures
cause microtubules to detach from spindles
arrests mitosis in metaphase
Affects all fast-dividing cells like bone marrow, and epithelial cells
Vincristine side effects
Peripheral neuropathy
hyponatremia
constipation
hair loss
fetal harm if pregnant
fertility impairment