Neurologic Diseases of Measles Virus Infection

These flashcards cover the key neurologic diseases associated with measles virus infection, including their onset, prognosis, clinical features, and pathological mechanisms.

What are the three neurologic diseases associated with measles virus infection?

Acute Disseminated Encephalomyelitis (ADEM), Measles Inclusion Body Encephalitis (MIBE), Subacute Sclerosing Panencephalitis (SSPE)

When does Acute Disseminated Encephalomyelitis (ADEM) usually onset?

1–2 weeks after rash onset.

Who does Measles Inclusion Body Encephalitis (MIBE) primarily affect?

Immunosuppressed individuals of any age.

What is the onset timing for Subacute Sclerosing Panencephalitis (SSPE)?

6–10 years after measles; sometimes decades later.

What triggers the autoimmune demyelinating disease in ADEM?

Measles antigen.

What is the prognosis for Acute Disseminated Encephalomyelitis (ADEM)?

Up to 90% favorable outcome; some lasting deficits for the other 10%.

What characterizes the clinical features of Subacute Sclerosing Panencephalitis (SSPE)?

Behavioral decline, intellectual deterioration, myoclonic jerks, seizures, and visual loss.

What is a notable pathological feature observed in SSPE?

Neurons and oligodendrocytes contain inclusion bodies but no virus buds from the surface.

What is the typical age of onset for neurologic disease in SSPE?

8 to 10 years of age, but can be reported up to age 35.

What is the outcome of Subacute Sclerosing Panencephalitis (SSPE)?

Usually progresses to coma and death; generally fatal.