Stimuli & Response, Receptors, Nerve impulses, Synaptic Transmission

What does the central nervous system include

Brain and Spinal Cord

What does the peripheral nervous system include

Sensory System and

Motor System

• Voluntary

• Automatic

- Sympathetic

- Parasympathetic

Label the structure of this motor neuron

Where do sensory neurones carry impulses to and from 

carry impulses from receptors to the intermediate neurone or the brain​

Where do intermediate neurones carry impulses to and from

interpret impulses, connect sensory and motor​

Where do motor neurones carry impulses to

carry impulses to the muscles and glands

Describe the first phase of the action potential - resting potential

• Is an un-stimulated axon / nerve fibre i.e. the neurone is not firing (no nerve impulse)​

• Resting cells are (-) inside and (+) outside​

• The maintenance of a resting potential is an active process (i.e. ATP dependent) that is controlled by sodium-potassium pumps​

• 3Na+ are pumped outside the axon and 2K+ pumped into the axon​ by active transport

• Sodium voltage gated channels closed​

• Potassium voltage gated channels closed​

• Other potassium ion channels are open, the membrane is more permeable to potassium​

• Sodium diffuses in, potassium diffuses out

• This creates an electrochemical gradient whereby the cell interior is relatively negative compared to the extracellular environment (as there are more positively charged ions outside of the cell and more negatively charged ions inside the cell)​

• Polarised membrane of -70mv

Define membrane potential of an axon

Differences of charges across the plasma membrane

Define threshold level

voltage required to initiate Action Potential (-55mv)

What is the all or nothing principle 

• Neurons fire all maximally or none at all​

• Increasing the intensity of the stimuli above the critical threshold value will not produce an increased response​

• The intensity of the nerve impulse and speed of transmission remain the same.

How can we tell the difference between a strong and weak stimulus

Number of nerve impulses – stronger stimulus = more impulses.​

Describe the process of depolarisation during an action potential

• Depolarisation refers to a sudden change in membrane potential – usually from a (relatively) negative to positive internal charge​

• In response to a signal initiated at a dendrite, voltage gated sodium channels open within the membrane of the axon​

• As Na+ ions are more concentrated outside of the neuron, the opening of sodium channels causes a passive influx of sodium​

• The influx of sodium causes the membrane potential to become more positive ​
  (+40mv) (depolarisation)​

• This is the action potential. The more Na+ moving in causes more VGC to open causing more Na+ to move in – this is positive feedback and shown by the steep curve of the graph

Describe the process of repolarisation during an action potential

• Repolarisation refers to the restoration of a membrane potential following depolarisation (i.e. restoring a negative internal charge)​

• Following an influx of sodium, potassium voltage gated ion channels open within the membrane of the axon. +40mv the voltage gated sodium channels close and the potassium voltage gated channels open.​

• As K+ ions are more concentrated inside the neuron, opening potassium channels causes a passive efflux of potassium​

• The efflux of potassium causes the membrane potential to return to a more negative internal differential (repolarisation)​

• Positive outside axon - Negative inside axon​

What is tropism

Growth of a part of a plant in response to a directional stimulus

What does IAA do in plant roots vs shoots

It stimulates cell elongation in shoots

It inhibits cell elongation in roots

Describe the process of positive phototropism in plant shoots

• Cells at the tip of the shoot produce IAA, which is then transported down the shoot.

• Initially it is transported evenly throughout all regions as it begins moving down the shoot.

• Light causes IAA to move from the light side to the shaded side of the shoot.

• IAA causes elongation of shoot cells so more IAA on shaded side means that cells on shaded side elongate more.

• Shaded side of shoot elongates faster than light side – shoot tip bends towards light

Describe the process of negative phototropism in plant roots

• Cells in the root tip make IAA.

• Initially it is transported evenly throughout the root as it moves down.

• Light causes IAA to move to the shaded side of the root.

• IAA causes inhibition of cell elongation of root cells.

• Cells on shaded side will elongate less due to more IAA on shaded side.

• Root tip bends away from the light.

What is the advantage of plants having a positive phototropic response in their shoots and negative phototrophic response in their roots?

Positive in shoots - increase photosynthesis

Negative in roots - root grow into ground towards nitrates and phosphates 

Describe the process of positive gravitropism in roots

• Cells at the tip of the root produce IAA, which is then transported along the root.

• Initially it is transported evenly throughout all sides of the root.

• Gravity causes IAA to move from the upper side to the lower side of the root.

• IAA inhibits elongation of root cells so more IAA on lower side means that cells on this side elongate less than upper side.

• ie greater elongation on upper side so root bends downwards towards gravity.

Describe the process of negative gravitropism in shoots

• Cells at the tip of the shoot produce IAA, which is then transported along the shoot

• Initially it is transported evenly throughout all sides of the shoot.

• Gravity causes IAA to move from the upper side to the lower side of the shoot.

• IAA stimulates elongation of shoot cells so more IAA on lower side means that cells on this side elongate more than upper side.

• ie greater elongation on lower side so root bends upwards away from gravity.

What is hyperpolarisation

Membrane potential = -80mz

Voltage gated sodium channels close

Voltage gated potassium channels close slowly therefore excessive effluent of potassium

Positive outside, Negative inside

What is the refractory period

The period of time following a nerve impulse before the neuron is able to fire again

In a normal resting potential, sodium ions are predominantly outside the axon and potassium ions are inside

After depolarisation, this ionic distribution is reversed

Before a neuron can fire again, the resting potential must be restored via the action of the sodium-potassium pump

How is propagation of action potential carried out along a non-myelinated axon

Ion channels in the axon are voltage gated

Depolarisation at one axon segment triggers the opening of ion channels in next segment

Consequently, the action potential spreads along the axon as a wave of depolarisation

How is propagation of action potential carried out along a myelinated axon and why is this faster than in a non-myelinated axon

No action potential can occur in myelinated areas

They have to be initiated at the nodes of ranvier

Action potential jumps from node to node

Faster because action potential/depolarisation doesn’t travel entire length of axon

Explain the three factors that impact speed of a nerve impulse

• Myelination

- Myelinated axons speed up nerve impulses because AP jumps from node to node instead of travelling entire axon

• Axon diameter

- In larger axons, positive ions tend not to leak as much as narrow axons. This means the membrane potential is more easily maintained

• Temperature

- Molecules move faster at higher temperatures, therefore rate of diffusion of ions will increase.

- Also, ATP from respiration required for sodium-potassium pump. Rate of respiration increases in higher temperatures because efficiency of respiration enzymes increases

What is the function of a synapse

A synapse conveys action potential between neurones

Label this synapse

What happens at the cholinergic synapse

• An action potential arrives at presynaptic membrane V.G and calcium channels in the presynaptic neurone open.

• Calcium ions enter the presynaptic neurone by facilitated diffusion causing synaptic vesicles to fuse with the presynaptic membrane realising acetylcholine into the synaptic cleft

• Acetylcholine diffuses across the synaptic cleft and binds to specific neuroreceptor sites in the post synaptic membrane. These are chemically gated sodium ion channels

• Sodium channels open and sodium ions diffuse into the poststynaptic membrane causing depolarisation which may initiate an action potential

• Acetylcholinesterase breaks down acetylcholine into choline and ethanoic acid. The products diffuse back into the presynaptic neuron via to reuptake protein

• Acetylcholine is re synthesised using ATP from the mitochondria and is stored in the synaptic vesicles. Sodium ion channels in post synaptic neurone close in absence of neurotransmitters

What feature of the synapse allows fro transmission to be unidirectional

• Only neurotransmitters made in presynaptic neurone

• Only receptors on post synaptic neurone

What is spatial summation

Several presynaptic neurones release to one postsynaptic neurone so enough neurotransmitters to exceed threshold value for an action potential

What is temporal summation

• One presynaptic neurone releases neurtotransmitters many times in a short period to exceed the threshold value for action potential