disorders of sexual development

Turners syndrome

-only X chromosome

-underdeveloped ovaries

-female external traits

-no menstruation

Klinefelters syndrome

-xxy chromosome

-undersized Male genitalia

-potential feminine secondary traits

-sterile

Congenital Adrenal Hyperplasia CAH

-LACK 27 HYDROXYLASE WHICH BLOCKS TEROID PRODUCTION AND INCREASES ANDROGEN PRODUCTION

-Female fetuses expose become partially masculinized

*most common cause of intersex

androgen insensitivity

absence of androgen receptors in xy males → will develop feminine features

DHT Deficient Males

genetic variation that doesnt allow testosterone to be converted to dht leading to ambiguous genitalia at birth and potential for male gender identity at puberty.