Neutrophils vs Macrophages
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8 Terms
What is the origin of Neutrophils?
HSCs in bone marrow - myeloid lineage cells
What is the origin of macrophages?
blood monocytes - derived from HSCs (in inflammatory reactions)
tissue resident - derived from stem cells in yolk sac or fetal liver (early in development)
What is the lifespan of Neutrophils?
1-2 days
What is the lifespan of Macrophages
inflammatory - days-weeks
tissue resident - years
What type of phagocytosis do neutrophils have?
rapid ingestion of microbes
What type of phagocytosis do macrophages have?
prolonged ability to ingest microbes, apoptotic cells, tissue debris, foreign material
Which has the more reactive oxygen species?
neturophils - rapidly induced by assembly of phagocyte oxidase
Which has higher levels of nitric oxide?
macrophages - induced after trasncriptional activation of iNOS - enzyme response in macrophage
Note 
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