Hexose Monophosphate Shunt Steps

1. Glucose-6-Phosphate

Glucose-6-Phosphate Dehydrogenase

2. 6-Phosphogluconolactone

Glucolactonase

3. 6-Phosphogluconate

6-Phosphogluconate Dehydrogenase

4. Ribose-5-Phosphate

Isomerase or Epimerase

5. R-5-P Isomerase

Ribose-5-Phospate

5. R-5-P Epimerase

Xylulose-5-Phosphate

6. R-5-P + Xylulose-5-Phosphate

Transketolase

7. Glyceraldehyde-3-Phosphate

Can go to glycolysis or Transaldolase

7. Sedoheptulose-7-Phosphate

Transaldolase

8. Fructose-6-Phosphate

Glycolysis

8. Erythrose-4-Phosphate +Xylulose-5-Phosphate

Transketolase

9. GA3P

Glycolysis8.

9. Fructose-6-Phosphate

Glycolysis

Oxidative Phase

Make NADPH and Ribose-5-Phosphate

Nonoxidative Phase

Carbon shuffling, R-5-P without NADPH, R-5-P to Glycolsis

NADPH

Great Reducing Agent

(Fatty acid synthesis

Cholesterol Metabolism

Nucleotide Synthesis

Neurotransfer Synthesis)

Ribose-5-Phosphate

Makes nucleotides

(DNA, RNA, ATP, CoA Synthesis, Electron Shuffles)