MICROPARA LEC MIDTERM - Clostridium tetani
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14 Terms
Description
Causes tetani
Description
Common O antigen → found in cell wall
Description
Produce same antigenic type of neurotoxin, tetanospasmin
Description
Not communicable
Pathogenesis
Block inhibitory mediators (glycine, GABA (CNS)) resulting to muscle spasm, spastic paralysis
Pathogenesis - portal entry
Wound
Pathogenesis - growth of C. Tetani
necrotic tissue
CA2+ salt
Pyogenic infections
Forms
Trismus - lockjaw
Form - Opisthotonos
Severe muscle pain
Form
Neonatal tetanus
Treatment
Tetanus toxoid (aluminum salt-adsorbed)
Treatment
Pentavalent (DPT-Hep B-HIB)
Treatment - muscle relaxant
IV tetanus antitoxin
Drug of choice
Penicillin tetanus antitoxin + toxoid booster w/ penicillin (active-passive immunity) - for dangerous wounds
Note 
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