[PHARMACOLOGY] Cell Wall Inhibitors

Beta lactamase inhibitor

[CLASSIFICATION] Clavulanic acid

Beta lactamase inhibitor

[CLASSIFICATION] Sulbactam

Extended spectrum penicillin

[CLASSIFICATION] Amoxicillin (specific type)

Antipseudomonal (carboxypenicillin)

[CLASSIFICATION] Carbenicillin (specific type)

Antipseudomonal (carboxypenicillin)

[CLASSIFICATION] Ticarcillin (specific type)

Antipseudomonal (ureidopenicillin)

[CLASSIFICATION] Mezlocillin (specific type)

Antipseudomonal (ureidopenicillin)

[CLASSIFICATION] Piperacillin (specific type)

Extended spectrum penicillin

[CLASSIFICATION] Ampicillin (specific type)

Narrow spectrum (natural penicillin)

[CLASSIFICATION] Benzylpenicillin (specific type)

Antistaphylococcal (Beta-lactamase resistant penicillin)

[CLASSIFICATION] Nafcillin (specific type)

Antistaphylococcal (Beta-lactamase resistant penicillin)

[CLASSIFICATION] Methicillin (specific type)

Antistaphylococcal (Beta-lactamase resistant penicillin)

[CLASSIFICATION] All -oxacillins

Cephalosporin (1)

[CLASSIFICATION] Cefazolin (and generation)

Cephalosporin (1)

[CLASSIFICATION] Cefadroxil (and generation)

Cephalosporin (2)

[CLASSIFICATION] Cefuroxime (and generation)

Cephalosporin (2)

[CLASSIFICATION] Cefamandole (and generation)

Cephalosporin (2)

[CLASSIFICATION] Cefmetazole (and generation)

Cephalosporin (2)

[CLASSIFICATION] Cefotetan (and generation)

Cephalosporin (2)

[CLASSIFICATION] Cefprozil (and generation)

Cephalosporin (3)

[CLASSIFICATION] Ceftriaxone (and generation)

Cephalosporin (3)

[CLASSIFICATION] Ceftazidime (and generation)

Cephalosporin (3)

[CLASSIFICATION] Cefdinir (and generation)

Cephalosporin (4)

[CLASSIFICATION] Cefepime (and generation)

Cephalosporin (4)

[CLASSIFICATION] Cefpirome (and generation)

Cephalosporin (5)

[CLASSIFICATION] Ceftobiprole (and generation)

Cephalosporin (5)

[CLASSIFICATION] Ceftaroline (and generation)

Cephalosporin (5)

[CLASSIFICATION] Ceftolozane (and generation)

Cephalosporin (2)

[CLASSIFICATION] Loracarbef (and generation)

Cephalosporin (1)

[CLASSIFICATION] Cephradine (and generation)

Cephalosporin (1)

[CLASSIFICATION] Cephalexin (and generation)

Carbapenem

[CLASSIFICATION] Imipenem

Carbapenem (as adjunct)

[CLASSIFICATION] Cilastatin

Carbapenem

[CLASSIFICATION] Meropenem

Glycopeptide

[CLASSIFICATION] Vancomycin, telavancin, teicoplanin, oritavancin

Lipopeptide

[CLASSIFICATION] Daptomycin

Peptide

[CLASSIFICATION] Bacitracin

Antimetabolite

[CLASSIFICATION] Cycloserine

Antimetabolite

[CLASSIFICATION] Fosfomycin

Monobactam

[CLASSIFICATION] Aztreonam

Binds to penicillin binding proteins

[MOA] All beta lactams

Inhibits transglycosylation by binding to D-Ala—D-Ala terminals

[MOA] Vancomycin

Blocks incorporation of D-ala via inhibition of ALANINE RACEMASE

[MOA] Cycloserine

Stops N-am synthesis via inhibition of ENOYLPYRUVATE TRANSFERASE

[MOA] Fosfomycin

Suicide substrates (permanently binds with beta-lactamase to keep their partner penicillins alive)

[MOA] Beta lactamase inhibitors

Prolonged pen G (ex. Benzathine pen G)

[DoC] Syphilis

Ceftriaxone

[DoC] Gonorrhea

Ceftriaxone

[DoC] Meningococcemia

Pen G

[DoC] Pneumococcal pneumonia

Antistaphylococcal pens (oxacillins)

[DoC] Staphylococcus aureus

Vancomycin

[DoC] MRSA (first line)

Vancomycin, 3rd and 4th gen penicillins

[DoC] PRSP

Either antipseudomonal penicillins (CTMAP) or 4th-5th gen cephalosporins

[DoC] Pseudomonas aeruginosa

Cefuroxime

[DoC] Community acquired pneumonia

Cefazolin (and it is also the only 1st gen given IV)

[DoC] Surgical prophylaxis

First gen cephalosporins

[DoC] Strep throat

Ceftazidime (also cefepime)

[Use] Febrile neutropenia

5th gen cephalosporins

[DoC] MRSA (alternative to vancomycin)

Carbapenems

[Use] Gram positives (as last line)

Monobactams (aztreonam)

[Use] Gram negatives (as last line)

2nd gen cephalosporins

[Use] Anaerobics (except metronidazole)

Daptomycin

[DoC] VRSA and VRE

Cycloserine

[Use] TB as second line

Fosfomycin

[Use] UTI as a single dose

Vancomycin

[Use] Pseudomembranous colitis

Vancomycin

[ADR] Red man syndrome

Myopathy

[ADR] Myopathy

Cycloserine

[ADR] Neurotoxicity

Cephalosporins, bacitracin

[ADR] Nephrotoxicity

Imipenem

[ADR] Seizures

MMOO (cefMetazole, cefaMandole, cefOperazone, cefOtetan)

[ADR] Hypoprothrombinemia and disulfiram-like reactions

Oxacillin

[ADR] Hepatitis

Nafcillin

[ADR] Neutropenia

Methicillin

[ADR] Interstitial nephritis

Ampicillin

[ADR] Pseudomembranous colitis

Ampi and amoxicillin

[ADR] Rash

Ertapenem

[ADR] Pain at injection site

Cephalexin

[SPECIFICS] First oral 1st gen cephalosporin

Tazobactam

[SPECIFICS] Partner BLI of piperacillin

Sulbactam

[SPECIFICS] Partner BLI of ampicillin

Clavulanic acid

[SPECIFICS] Partner BLI of amoxicillin

-cidal

[SPECIFICS] All cell wall inhibitors are bacterio___

Nafcillin

[SPECIFICS] Only antistaphylococcal penicillin excreted only in bile

Methylthiotetrazole

[SPECIFICS] Ring that causes hypoprothrombinemia in some cephalosporins

3rd

[SPECIFICS] Entry to the BBB starts with what generation of cephalosporins?

4th

[SPECIFICS] Antipseudomonal activity in cephalosporins starts with what generation?

5th

[SPECIFICS] MRSA activity in cephalosporins starts with what generation?

Ceftazidime, cefoperazone

[SPECIFICS] Only 3rd gen cephs that works on Pseudomonas

Ceftolozane-tazobactam, ceftazidime-avibactam

[SPECIFICS] Recent cephalosporin-BLI combinations

Bacitracin

[SPECIFICS] Only limited to topical use

Streptomyces roseosporus

[SPECIFICS] Bacterial source of daptomycin

Streptomyces orchidaceious

[SPECIFICS] Bacterial source of cycloserine

Bacillus subtilis

[SPECIFICS] Bacterial source of bacitracin

Clostridium difficile

[CAUSATIVE] Pseudomembranous colitis

Treponema pallidum

[CAUSATIVE] Syphilis

Neisseria meningitidis

[CAUSATIVE] Meningococcemia

Streptococcus pneumonia

[CAUSATIVE] Community acquired pneumonia

Neisseria gonorrheae

[CAUSATIVE] Gonorrhea

Amoxicillin

[SPECIFICS] Penicillin that is orally available and unaffected by food