Dopamine and Serotonin 911

What do D2 agonists treat

Parkinson’s

Bromocriptine

What do D2 antagonists treat

Antipsychotics

Antiemetic

chloropromazine

Haloperidol

Clonzapine

What do D3 agonists mainly treat

Antipsychotics

Apomorphine

Pramipexole

Rotigotine

What do D2/3 partial agonists treat

Antipsychotics

Aripiprazole

Brexpipazole

What do DAT (transporters) inhibitors treat

ADHD, Depression

Cocaine

methylphenidate

What do D2/D3 agonists treat

Parkinson’s and Restless leg syndrome

Bromocriptine

Pergolide

Pramipexole

Ropinirol

What do D2 antagonists normally treat

Schizophrenia

chlopromazoine

haloperidol

Prochlolperazine

Quetiapine

Olanzapine

What type of antipsychotics Can cause Parkinson’s like symptoms?

Typical:

Haloperidol

Chlorpromazine

Atypical antipsychotics

Quetiapine

Prochloperazine

Olanzapine

What do DA metabolism reuptakers mainly treat

ADHD, Depression, Parkinson’s

Methylphenidate

Bupropion

Lisdexamfetamine

Carbidopa/Levodopa

Meth

AMPH

Aripripazole:

Partial DA 2/3 Agonst

Bupropion:

DA reuptake inhibitor

Dexmethylphenidate:

DA reuptake inhibitor

Indirect acting Dopaminergic drugs

• Releasers

• Reuptake inhibitors

• Metabolism inhibitors

5-HT1A: Partial Agonist

Buspirone

Isaperone

Anxiety and depression

5-HT1D: agonist

Sumatriptan

Migrane

5-HT 2A/2C antagonist

Risperidone

Schitzophreia Depression

5-HT2A/2C: Agonist

Psilocybin: Depression

5-HT3 antagonist

Zofran

Chemo-induced nausea

5-HT4 agonist

Tegaserod

Cisapride

GI disorder

SERT (5-HT Transporter) Reuptake Inhibitors

Fluoxetine

Sertraline

Amtriptyline

Citalopram

Duloxetine

Paroxetine

Depression/OCD

5-HT2A receptor Antagonists

Lursidone

Ziprasidone

Vilazodone

Risperidone

Atypical antipsychotics

5-HT3 Antagonist

Troisetron

Zofran

Granisetron

5-HT4 Antagonist

Emesis

meoclopramide

5-HT1D: Agonists

Antimigrane

Electric tan

Rizatriptan

Sumatriptan

5-HT1A: Receptor agonists

Anxiety/Depression

Buspirone

Geprione

Isapirone

Trazodone

5-HT2A agonistst

Psychedelics

LSD

Psilocyloin

Bretisilocin

Ecstasy

DOB

What causes Parkinson’s

Lack of Dopamine