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What are the two competing behavioral states
appetite (or hunger) and satiety
appetite
desire for food
satiety
sense of fullness (or satisfaction)
what two key control centers belong to the hypothalamus
feed center and satiety center
what are the four types of input to the hypothalamus?
- neural input from cerebral cortex
- neural input from limbic system
- peptide hormones from GI tract
- adipocytokines from adipose tissue
what do adipose tissues do
they store fat
- signaling molecules that affect the hypothalamus
Glucostatic theory
- theory on regulation of food intake
- blod glucose levels control the feeding and satiety center
lipostatic theory
- theory on regulation of food intake
- fats regulate the feeding and satiety centers
which of the two - theories on regulation of food intake is more accepted and why?
lipostatic theory because we have adipose tissues that store fat
which two peptides support the lipostatic theory
leptin and neuropeptide Y
energy output equation
heat+work
what are the three categories of work done by cell?
- membrane transport: such as Na/K pump
- Mechanical work: actually movement of body thru muscles
- chemical work: building and breaking molecules (anabolism/catabolism)
what is short term energy storage
ATP, want to use it right away
what is long term energy storage
gylcogen and fat, want to store it use it when it's necessary (breakdown of glucose to get energy)
Direct colimertry
- method of measuring energy use
- measure energy content of food; calorie counting
indirect caloirmetry
- method of measuring energy use
- measuring how much your body burns
- estimates metabolic rate
what are the two components of measuring metabolic rate
ratio of Oxygen consumption to carbon dioxide production
what is the most common measure of metabolic rate
basal metabolic rate
what are six factors that affect metabolic rate and how
1. age/ gender: young males are faster
2. amount of lean muscle: more muscle, faster
3. activity level: more active, faster
4. energy intake (diet): more food, faster
5. hormones: secrete hormones at different age
6. genetics: some people have genes that make them faster
how is glycogen (highly branched polymer of glucose) used to store energy
-stored glycogen binds water
- liver glycogen regulate blood glucose
- muscle glycogen powers muscle contraction
how is fat (triglyceride) used to store energy
- fats have higher energy content per gram
- little water is required for fat storage
- energy in fats is harder and slower to access
two types of metabolic pathway and what do they do?
1. anabolic: building of molecules
2. catabolic: breakdown of molecules
what is done with energy in metabolism
1. extract energy from nutrients
2. use energy for work and synthesis
3. store excess energy
lipogenesis v lypolysis
formation of fat vs breaking down to fat to free fatty acid
gluconeogenesis vs glycogenolysis
formation of glucose vs breakdown of glucose
fed state and what process are results of it
-eating
- increase secretion of insulin
- result in glucose oxidation, glycogen synthesis, fat synthesis, protein synthesis
fasted state
- not eating
- increase secretion of glucagon
- results in glycogenolysis, gluconeogenesis, ketogenesis