DA Exam 3 Drugs to Know

Tricyclic Antidepressant

Imipramine (Tofranil)

SSRIs

Fluoxetine (Prozac)

Paroxetine (Paxil)

Sertraline (Zoloft)

Citalopram (Celexa)

SNRI

Duloxetine (Cymbalta)

NRI

Reboxetine

Atypical Antidepressants

Bupropion (Wellbutrin)

Mirtazapine

Nefazodone and Trazodone

5-HT₁ Agonists

Buspirone

Sumatriptan

5-HT Antagonists

Ketanserin (5-HT₂)

Ondansetron (5-HT₃)

Mood stabilizers

Carbamazepine (Tegretol)

Valproic Acid (Depakote)

Lithium (Lithotab)

CNS Stimulants (inhibit 5-HT storage)

Amphetamines (Adderall)

Methylphenidate (Ritalin)

GABA release inhibitor

Tetanus toxin

GABA Metabolism Inhibitor

Tiagabine

Vigabatrin

GABA_A Receptor Agonist

Muscimol

GABA_A receptor antagonist

Biscuculline

Picrotoxin

GABA_A inverse agonist

B-carbolines

Benzodiazepines (GABA_A agonists)

Alprazolam (Xanax)

Clonazepam (Klonopin)

Diazepam (Valium)

Lorazepam (Ativan)

Midazolam

Non-Benzodiazepine Hypnotic

Zolpidem (Ambien)

Diazepam clinical uses

• anxiety

• epilepsy

• muscle relacant

• IV general anesthetic

• alcohol withdrawl

Benzodiazepine Antagonist (GABA_A antagonist)

Flumazenil

Barbiturates (GABA_A Agonists)

Phenobarbital (Luminal)

Thiopental (Pentothal)

Pentobarbital (Nembutal)

GABA_B Receptor Agonist

Baclofen

Non-Rx GABA Drugs

• Ethanol

• GHB

• Flunitrazepam (Rohypnol)

Inhalational Anesthetics that target NMDA

• NO

• Xenon

• Cyclopropane

• Halothane (Fluothane)

• Enflurane

• Desflurane (Suprane)

• Isoflurane (Forane)

• Sevoflurane (Ultane)

Inhalational Anesthetics that target GABAa

• Halothane (Fluothane)

• Enflurane

• Desflurane (Suprane)

• Isoflurane (Forane)

• Sevoflurane (Ultane)

IV Anesthetics that target GABAa

• Propofol

• Barbiturates

• Benzodiazepines

• Etomidate

IV Anesthetics that target NMDA

ketamine

IV anesthetics that target alpha-2 adrenergic receptor

dexmedetomidine

Naturally occurring opioids

• Morphine

• Codeine (methylmorphine)

Semisynthetics opioids

• Oxycodone

• Hydrocodone

• more potent

Synthetic opioids

• Meperidine

• Methadone

  • used to achieve sustained relief of chronic pain

• Fentanyl

• Sufentanil

Partial and Mixed Opioid Agonists

• Buprenorphine

Opioid receptor antagonists

• naloxone

• naltrexone

Migraine therapy drug

Sumatriptan

Drugs that target Cox-1 and cox-2 receptors

• NSAIDs

  • aspirin

  • ibuprofen

  • naproxen

  • diclofenac

  • ketorolac

  • celecoxib (cox-2 selective)

• Acetaminophen (mechanism unknown)

Drug used to treat all types of seizures

Valproate

Drug that can treat all but one type of seizure

Lamotrigine

AEDs that inactivate sodium channels

• Phenytoin

• Carbamazepine

• Valproic acid

• Lamotrigine

AEDs that inhibit Calcium channels

• Ethosuximide

• Valproic acid

• gabapentin and pregabalin

AEDs that activate potassium channels

Ezogabine (Retigabine)

AEDs that enhance GABA

• Barbiturates

• Benzodiazepines

• Vigabatrin

AEDs that inhibit Glutamate receptors

• Felbamate

• Perampanel