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mature erythrocyte
lasts 4 months (apoptosis)
a lot smaller than what it started as
more surface area bc of no nuclus to carry more HEMOGLOBIN
what phase of erythropoiesis ejects the nucleus
orthochromatic erythroblast
1-7 days phase
proerythroblast --> basophilic erythroblast --> prolychromatic erythroblast --> orthochromatic erythroblast --> reticulocyte
erythropoiesis
process of RED blood cell formation
red bone marrow --> hematopoietic stem cell --> myeloid stem cell --> [proerythroblast --> basophilic erythroblast --> polychromatic erythroblast --> orthochromatic erythroblast --> reticulocyte] --> mature erythrocyte
how many cells are destroyed each hour
150 million RBC every hr
erythrocyte structure
biconcave shape allows RBCs to bend, fold, and "stack" to prevent blockage in tiny blood vessels
biconcavity also increases surface area for gas exchange
anucleate: no nucleus, carries very little DNA, unable to synthesize proteins
prone to apoptosis (programmed cell death :( @ 4mo/120 days)