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What are the 3 types of cartilage?
Hyaline, elastic, fibrocartilage
Where can hyaline cartilage be found?
Ends of bones, nose, trachea
Where can elastic cartilage be found?
External ear and epiglottis
Where can fibrocartilage be found?
Sites subjected to pressure and stretch
What makes hyaline cartilage resilient?
Fine collagen fibers
What makes elastic cartilage resilient?
Resemble hyaline cartilage, more stretchy
What makes fibrocartilage resilient?
Chondrocytes and thick collagen fibers
Describe short bone
Roughly cube shaped, includes sesamoid bones that alter direction of pull or reduce friction
Describe long bone
Elongated shape with a shaft and two ends
Describe flat bones
Thin, flat, usually curved
Describe irregular bones
Complicated shape
What is an example of a long bone?
Limb bones, like femur
What is an example of a short bone?
Wrist bones
What is an example of a flat bone?
Sternum
What is an example of an irregular bone?
Vertebrae
What are the major regions of the skeleton?
Axial and appendicular
What is the function of the axial skeleton?
Protect, support, or carry other body parts
What is the function of the appendicular skeleton?
Attached to limbs that help us move
What are the functions of the skeleton?
Support, hematopoisis, hormone production, protection, movement, mineral and growth factor storage, triglyceride storage
Describe the function of mineral storage of the skeleton
Bone is a reservoir for minerals like calcium and phosphate that are released into the bloodstream when needed
Describe the function of hematopoiesis of the skeleton
Blood cell formation
Describe the function of triglyceride storage of the skeleton
Fat is a source of energy for the body
Describe the function of hormone production of the skeleton
Osteocalcin is produced, regulateing bone formation and stimulates adiponectin
What are the gross anatomy components of a typical long bone?
Diaphysis, epiphyses, membranes. blood vessels and nerves
Describe the diaphysis in typical long bones
Shaft of bone that is made of a thick collar of compact bone that surrounds the marrow cavity which contains yellow marrow
Describe the epiphyses in typical long bones
Bone ends that have an outer shell of compact bone with a spongy bone interior, covered by a thin layer of articular cartilage
Describe the membranes in typical long bones
The periosteum covers the entire bone, supplied by nerve fibers and blood vessels
Describe the blood vessels and nerves in typical long bones
Nutrient artery and nutrient vein supply the diaphysis through the nutrient foramen
What is the location and function of red marrow?
Between trabeculae of spongy bones in flat bones and heads of long bones, hematopoisis
What is the location and function of yellow marrow?
Medullary cavity of the diaphysis, store fat
What is the location and function of articular cartilage?
Covers the ends of bones that form joints, provide smooth surface to facilitate joint movement
What is the location and function of periosteum?
Covers the external surface of the entire bone except joint surfaces, provides blood supply to bone
What is the location and function of endosteum?
Covers internal spongy bone surfaces, facilitates bone growth
What is the function and location of trabeculae?
Inside spongy bone, helps the bone resist stress
What is the function and location of compact bone?
Outer layer of long bones, provides strength and protection
What is the function and location of spongy bone?
Ends of long bones, provide structural support
What is the histology of the compact bone (osteon structure)?
Contains lamellae, interstitial lamellae, lacuna, and central canal
What is the lamellae?
Layers of bone tissue
What is the lacuna?
Where the cell lives
What is the central canal?
Blood vessels and nerves that provides tissue with nutrients
Describe the gross anatomy of a typical flat bone
Contains two thin plates of compact bone enclosing a spongy bone layer
What are the organic components of bone?
Carbon, oxygen, osteoids that contain proteins and enzymes
What are the inorganic components of bone?
Calcium and phosphate, including hydroxyapatite that forms the basis of bone tissue
What is the basic difference between intramembranous ossification and endochondral ossification?
Intramembranous ossification is when a bone develops to form a fibrous membrane, while in endochondral ossification is when a bone develops by replacing a hyaline cartilage
Describe the process of long bone growth that occurs at the epiphyseal plates
The epiphyseal plate is a layer of hyaline cartilage where ossification occurs, allowing the diaphysis to grow in length
Describe the differences between appositional growth and longitudinal growth
Appositional growth makes the bones thicker while longitudinal growth makes the bones longer
Where are osteoblasts located?
Periosteum and endosteum
Where are osteocytes located?
Lacuna
Where are osteoclasts located?
Sites of bone resorption
What is the remodeling function of osteoblasts?
Bone forming cells and matrix calcification
What is the remodeling function of osteocytes?
Monitor and maintain bone matrix
What is the remodeling function of osteoclasts?
Bone resorption, breaking down old or damaged bone tissue
Explain how hormones regulate bone remodeling
Parathyroid gland detects falling blood calcium levels and secretes PTH that tells osteoclasts to degrade bone and release more blood calcium into blood
Explain how physical stress / gravity regulates bone remodeling
Wolff’s law says that the bone grows or remodels according to mechanical demands placed upon it, signaling osteocytes to build new bone tissue or break down old bone tissue