clostridioides difficile

facts

• gram pos, endosporte forming rod

• normal in intestine

• causes pseudomembranous colitis

• cause of diarrhea

• able to superinfect th elarge intestien when have disrupted the normal microbiota

• enterotoxins a and b cause areas of necroses

signs and symptoms

• diarrhea in alte antibiotic therapu

• sever cases; absomincal cramps, fever, leukocytosis

• inflamed colon off of pseudomembranes

• perforation of the secum and death can result

prevention and dtreatment

• fecal transplant

• vancomycin, fidacomycin

• electrolyes

m

m