Evidence Based Practice and Research Methodology

Flashcards covering key concepts and vocabulary related to Evidence Based Practice and research methodology.

Evidence Based Practice Steps

Ask a clinical question, Access the best evidence, Appraise your results critically, Apply results to your patients, Assess your process.

I-BARF

Identify genuine and precise need, Build database, Assess critical factors, Analyze and synthesize, Response and recommendations, Follow up.

Tertiary Resources

Provide summarized information from primary and secondary sources, including textbooks, compendia, and systematic reviews.

Secondary Resources

References that index or abstract primary literature to direct users to the relevant research.

Primary Resources

Consists of original research studies and reports, including articles, surveys, and case reports.

Foreground Questions

Require research evidence to answer, focus on specific decisions such as comparing treatment options.

Background Questions

Broad queries that do not require research evidence and provide general knowledge about a population.

PICO

Problem/patient, Intervention, Comparison, Outcome - a framework for clinical questions.

Adverse Drug Reaction Classification by Severity

Categories include Minor, Moderate, Severe, Lethal based on the impact of the reaction.

Idiosyncrasy

An unusual response to a medication not typical for most individuals.

Hypersensitivity

Strong bodily reaction to a drug, often involving an allergic response.

Intolerance

Severe side effects from small doses of medication.

Drug Interaction

Effects when two or more medications influence each other, causing unusual responses.

Pharmacologic Effects

Predictable effects of a medication related to its dose.

Causality Determination

Evaluating the relationship between a drug and an adverse reaction using expert judgment and algorithms.

Dechallenge

The process of stopping a drug and monitoring the patient to assess for symptom resolution.

Rechallenge

Retrial of a medication after symptoms resolve to determine if the drug is the cause of the reaction.

Parametric Tests

Statistical tests assuming normal distribution of data, like Student’s t-test.

Non-Parametric Tests

Statistical tests not assuming normal distribution, like the Chi square test.

Type I Error

Incorrectly concluding a difference between treatments when there is none.

Type II Error

Incorrectly concluding no difference between treatments when one exists.

Study Designs

Includes observational studies, case reports, cross-sectional studies, case control, and cohort studies.

Clinical Guidelines Sources

Resources such as 'Up to Date' that provide up-to-date clinical information.