Intro to Neuropharm Mood Stabilizers and Depression

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7 Terms

1
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MAOI

Inhibition of MAO increases amount of neurotransmitter available for release

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Tricyclic antidepressants

bind to presynaptic transporter proteins, inhibiting reuptake of neurotransmitters, prolonging duration of transmitter action

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Amytriptyline

Drug reduces both NE ans 5-HT reuptake

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SSRIs

Block presynaptic 5-HT reuptake transporters more than NE transporters

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Mirtazapine

Blocks a2 autoreceptor, increasing synaptic NE and a2 receptors on serotonergic cells, increasing 5-HT release

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Lithium

Most effective treatment for bipolar disorder

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Lithium

Drug enhances 5-HT actions and reduces catecholamine activity