Ganglionic Blockers
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5 Terms
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What is the role of ganglionic blockers?
to block ACh at the ganglia
prevents target organ activation
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What are the distinct features of ganglionic blockers?
2 quaternary ammonium salts separated by 5-6 carbons
no substituents
NO RINGS
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hexamethonium bromide
6 carbons apart
quaternary amine
used for HTN in the past (not used anymore)
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Pentolinium Bromide
5 carbon spacer
used to control BP/severe HTN → pernicious HTN
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Mecamylamine
NO similarity to ACh
negative allosteric modulator for ACh binding at ganglia
indication: smoking cessation
Note 
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