Unit 10: Benign Disorders of Leukocytes

A benign increase in leukocytes due to infection of inflammation is known as a:

leukemoid reaction

Would these results indicate a leukemoid reaction or a true leukemia?

WBC count = 65 × 10⁹/L

Left shift = prominent

LAP = 120 (high)

leukemoid reaction

Would these results indicate a leukemoid reaction or a true leukemia?

WBC count = 1000 × 10⁹/L

Left shift = slight

LAP = 12 (low)

true leukemia

Bacterial infection, burns, and stressful situations can cause this change in neutrophils:

toxic granulation

What ribosomal RNA inclusion found in neutrophils can sometimes be seen during toxic granulations?

Dohle bodies

What ribosomal RNA inclusions found in neutrohils, lymphs, monos, and platelets are seen due to genetic mutations?

May-Hegglin anomaly

__________________ can occur to neutrophils under the same conditions that cause Dohle bodies and toxic granulation (bacterial infections, burns, stress).

vacuolization

(Pelger Huet/Pseudo Pelger Huet) anomaly is NOT clinically significant with normally functioning bi-lobed neutrophils.

Pelger Huet

(Pelger Huet/Pseudo Pelger Huet) anomaly is clinically significant with impaired bi-lobed hypogranular neutrophils.

Pseudo Pelger Huet

These mucopolysaccharide deposits are associated with Hurler’s and Hunter’s syndrome.

Alder-Reilly anomaly

What condition causes large lysosomal, peroxidase + granules in cells?

Chediak-Higashi anomaly

What childhood condition causes neutrophils to be unable to kill phagocytized organisms due to abnormal oxygen metabolism, causing granulomas in the surrounding tissue?

chronic granulomatous disease

What condition is shown?

chronic granulomatous disease

What test is used to detect chronic granulomatous disease?

NBT (nitroblue tetrazolium dye test)

What condition is a lipid storage disorder of macrophages caused by a deficiency of glucocerebrosidase?

Gaucher disease

What condition seen in Ashkenazid Jews is a lipid storage disorder of macrophages caused by a deficiency of sphingomyelinase?

Niemann-Pick disease

What conditions is caused by EBV and is accompanied by an increase in reactive lymphocytes?

infectious mononucleosis