Extracellular Matrix

Extracellular Matrix

External meshwork of polysaccharides and proteins

Functions

Strength, protections, structural support, organization, and cell signaling

Integrins

Proteins on the cell surface that function as receptors and mediate adhesion between the cell and its ECM

What is the role of integrins in cancer metastasis?

They help cancer cells break through tissue boundaries by mediating cell adhesion to the ECM, controlling cell migration/invasion, and transmitting signals that promote cell survival

Describe the composition of the ECM

Mainly composed of proteins, proteoglycans, and glycosaminoglycans (proteins and polysaccharides)

What is the relationship between the ECM and the cytoskeleton?

Interconnected by integrins; the ECM provides support and the cytoskeleton exerts force on the ECM

Adhesive Proteins

Fibronectin and laminin

Structural Proteins

Collagen and elastin

Proteoglycans

Form a gel-like substance between cells that helps the ECM resist compressive forces and allows for diffusion of nutrients and waste