Oncogenes and tumor suppressor genes USMLE Step1 first aid

Oncogene or tumor suppressor? Bcl-2

Oncogene

Oncogene or tumor suppressor? BRAF

Oncogene

Oncogene or tumor suppressor? C-kit

Oncogene

Oncogene or tumor suppressor? C-myc

Oncogene

Oncogene or tumor suppressor? Her2-neu (c-erbB2)

Oncogene

Oncogene or tumor suppressor?L-myc

Oncogene

Oncogene or tumor suppressor? n-myc

Oncogene

Oncogene or tumor suppressor?ras

Oncogene

Oncogene or tumor suppressor? Ret

Oncogene

Oncogene or tumor suppressor? APC

Tumor suppressor

Oncogene or tumor suppressor? BRCA1

Tumor suppressor

Oncogene or tumor suppressor? BRCA2

Tumor suppressor

Oncogene or tumor suppressor? CPD4/SMAD4

Tumor suppressor

Oncogene or tumor suppressor? DCC

Tumor suppressor

Oncogene or tumor suppressor? MEN1

Tumor suppressor

Oncogene or tumor suppressor? NF1

Tumor suppressor

Oncogene or tumor suppressor? NF2

Tumor suppressor

Oncogene or tumor suppressor?p16

Tumor suppressor

Oncogene or tumor suppressor? P53

Tumor suppressor

Oncogene or tumor suppressor? PTEN

Tumor suppressor

Oncogene or tumor suppressor? Rb

Tumor suppressor

Oncogene or tumor suppressor? TSC1

Tumor suppressor

Oncogene or tumor suppressor? TSC2

Tumor suppressor

Oncogene or tumor suppressor? VHL

Tumor suppressor

Oncogene or tumor suppressor? WT1

Tumor suppressor

Oncogene or tumor suppressor? WT2

Tumor suppressor

Associated tumor: BCR2-ABL

CML, ALL

Associated tumor: bcl-2

Follicular and undifferentiated lymphomas

Associated tumor: BRAF

Melanoma

Associated tumor: c-kit

Gastrointestinal stromal tumor (GIST)

Associated tumor: c-myc

Burkitt lymphoma

Associated tumor:HER2/neu (cerbB2)

Breast, ovarian, and gastric carcinomas

Associated tumor: L-myc

Lung tumor

Associated tumor: N-myc

Neuroblastoma

Associated tumor: ras

Colon cancer, lung cancer, pancreatic cancer

Associated tumor: ret

MEN2A& 2B

Associated tumor: APC

colorectal cancer (associates with FAP)

Associated tumor: BRCA1

Breast and ovarian Cancer

Associated tumor: BRCA2

Breast and ovarian Cancer

Associated tumor: CPD4/SMAD4

Pancreatic cancer

Associated tumor: DCC

Colon Cancer

Associated tumor: MEN1

MEN type 1 (pituitary adenoma, parathyroid tumors, and pancreatic endocrine tumors)

Associated tumor:NF1

Neurofibromatosis type 1 (cafe-au-lait spots, multiple neurofibromas, lisch nodules)

Associated tumor: NF2

Neurofibromatosis type 2

Associated tumor: p16

Melanoma

Associated tumor: p53

Most human cancers, Li-fraumeni syndrome

Associated tumor: PTEN

Breast cancer, prostate cancer, endometrial cancer

Associated tumor: Rb

Retinoblastoma, osteosarcoma

Associated tumor: TSC1

Tuberous sclerosis

Associated tumor: TSC2

Tuberous sclerosis

Associated tumor: VHL

Von Hippel-Lindau disease

Associated tumor: WT1

Wilms tumor (nephroblastoma)

Associated tumor: WT2

Wilms tumor (nephroblastoma)

Associated tumor: BCR2-ABL

CML, ALL

Associated tumor: bcl-2

Follicular and undifferentiated lymphomas

Associated tumor: BRAF

Melanoma

Associated tumor: c-kit

Gastrointestinal stromal tumor (GIST)

Associated tumor: c-myc

Burkitt lymphoma

Associated tumor:HER2/neu (cerbB2)

Breast, ovarian, and gastric carcinomas

Associated tumor: L-myc

Lung tumor

Associated tumor: N-myc

Neuroblastoma

Associated tumor: ras

Colon cancer, lung cancer, pancreatic cancer

Associated tumor: ret

MEN2A& 2B - both feature medullary carcinoma of the thyroid and pheochromocytomas; 2a= parathyroid hyperplasia, 2b= oral/intestinal ganglioneuromatosis

Associated tumor: APC

colorectal cancer (associates with FAP)

Associated tumor: BRCA1

Breast and ovarian Cancer

Associated tumor: BRCA2

Breast and ovarian Cancer

Associated tumor: CPD4/SMAD4

Pancreatic cancer

Associated tumor: DCC

Colon Cancer

Associated tumor: MEN1

MEN type 1 (parathyroid tumors, pituitary tumors, pancreatic endocrine tumors)

Associated tumor:NF1

Neurofibromatosis type 1 (cafe-au-lait spots, multiple neurofibromas, lisch nodules)

Associated tumor: NF2

Neurofibromatosis type 2 (bilateral acoustic neuromas)

Associated tumor: p16

Melanoma

Associated tumor: p53

Most human cancers, Li-fraumeni syndrome

Associated tumor: PTEN

Breast cancer, prostate cancer, endometrial cancer

Associated tumor: Rb

Retinoblastoma, osteosarcoma

Associated tumor: TSC1

Tuberous sclerosis

Associated tumor: TSC2

Tuberous sclerosis

Associated tumor: VHL

Von Hippel-Lindau disease

Associated tumor: WT1

Wilms tumor (nephroblastoma)

Associated tumor: WT2

Wilms tumor (nephroblastoma)

Associated tumor: MSH2, MLH1, MSH6, PMS2

genes are involved in mismatch repair and mutations in these genes cause Lynch syndrome, also known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) syndrome.

• Autosomal dominant

oncogene or tumor suppressor: MSH2, MLH1, MSH6, PMS2