Describe how drugs may behave as reversible or irreversible competitive antagonists of receptors for endogenous ligands

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4 Terms

1
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- Most common type of competitive antagonist.

- Is surmountable (higher concentrations of agonist can overcome it).

- Agonist will have same Emax but increased EC50.

Describe reversible competitive antagonist

2
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- Shifts curve to the right without change of slope.

What does a reversible competitive antagonist do to the concentration-effect curve?

3
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- Competes with agonist for same receptor site but binds irreversibly.

- Lower Emax and EC50.

- Rarely used clinically.

Describe irreversible competitive antagonist

4
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- Downward shift of the curve.

What does an irreversible competitive antagonist do to the concentration-effect curve?