Drug Quiz #5 - Urinary Antispasmodic, Prostate Anti-inflammatory, Urinary Bladder Modifier, Vasopressin Antagonist

Darifenacin (Brand Name)

Enablex

Darifenacin (Therapeutic Class)

Urinary Antispasmodic

Darifenacin (Drug Class, Indication)

Muscarinic (M3) antagonist; Overactive Bladder

Darifenacin (MOA)

Selective antagonist of the M3 muscarinic (cholinergic) receptor subtype limiting bladder contractions & symptoms of bladder irritability/overactivity

Darifenacin (Side Effects)

Constipation, xerostomia, blurred vision, dizziness

Dutasteride (Brand Name)

Avodart

Dutasteride (Therapeutic Class)

Prostate Anti-inflammatory

Dutasteride (Drug Class, Indication)

5α-Reductase Inhibitor; Benign prostatic hyperplasia

Dutasteride (MOA)

Inhibits the conversion of testosterone to 5α-dihydrotestosterone (DHT) by 5α-reductase

Dutasteride (Side Effects)

Impotence, decreased libido, ejaculation disorder, gynecomastia

Finasteride (Brand Name)

Proscar

Finasteride (Therapeutic Class)

Prostate Anti-inflammatory

Finasteride (Drug Class, Indication)

5α-Reductase Inhibitor; Benign prostatic hyperplasia, Male pattern alopecia

Finasteride (MOA)

Inhibits the conversion of testosterone to 5α-dihydrotestosterone (DHT) by 5α-reductase

Finasteride (Side Effects)

Impotence, decreased libido, ejaculation disorder, gynecomastia

Mirabegron (Brand Name)

Myrbetriq

Mirabegron (Therapeutic Class)

Urinary Bladder Modifier

Mirabegron (Drug Class, Indication)

Beta-3 agonist; Overactive bladder, Neurogenic detrusor overactivity

Mirabegron (MOA)

Activates β3-adrenergic receptors resulting in relaxation of the detrusor smooth muscle and increasing bladder capacity

Mirabegron (Side Effects)

Hypertension, tachycardia, palpitations, blurred vision, confusion

Oxybutynin (Brand Name)

Ditropan (XL)

Oxybutynin (Therapeutic Class)

Urinary Antispasmodic

Oxybutynin (Drug Class, Indication)

Muscarinic (M3) antagonist; Overactive or neurogenic bladder

Oxybutynin (MOA)

Inhibits muscarinic action of acetylcholine on smooth muscle to relax bladder smooth muscle

Oxybutynin (Side Effects)

Dry mouth, drowsiness, constipation, blurry vision

Solifenacin (Brand Name)

Vesicare

Solifenacin (Therapeutic Class)

Urinary Antispasmodic

Solifenacin (Drug Class, Indication)

Muscarinic (M3) antagonist; Overactive bladder, Neurogenic detrusor overactivity

Solifenacin (MOA)

Inhibits muscarinic receptors resulting in decreased urinary bladder contraction, increased residual urine volume, and decreased detrusor muscle pressure.

Solifenacin (Side Effects)

Constipation, xerostomia, blurred vision, dizziness

Tamsulosin (Brand Name)

Flomax

Tamsulosin (Therapeutic Class)

Prostate Anti-inflammatory

Tamsulosin (Drug Class, Indication)

α1-Adrenergic Blocker; Benign prostatic hyperplasia

Tamsulosin (MOA)

Blocks alpha-1 receptors relaxing smooth muscle tone in the bladder neck and prostate.

Tamsulosin (Side Effects)

Headache, rhinitis, dizziness, abnormal ejaculation, orthostatic hypotension

Tolterodine (Brand Name)

Detrol (LA)

Tolterodine (Therapeutic Class)

Urinary Antispasmodic

Tolterodine (Drug Class, Indication)

Muscarinic (M3) antagonist; Overactive bladder

Tolterodine (MOA)

Competitive antagonist of muscarinic receptors increasing residual urine volume and decreases detrusor muscle pressure.

Tolterodine (Side Effects)

Dry mouth, constipation, dizziness/vertigo, somnolence, indigestion

Tolvaptan (Brand Name)

Samsca, Jynarque

Tolvaptan (Therapeutic Class)

Vasopressin Antagonist

Tolvaptan (Drug Class, Indication)

Vasopressin (V2) antagonist; Hyponatremia, Polycystic kidney disease (autosomal dominant)

Tolvaptan (MOA)

Antagonizes the effect of vasopressin resulting in increases in urine water excretion, increasing free water clearance, and a decrease in urine osmolality, resulting in the restoration of normal serum sodium levels and can inhibits cyst growth.

Tolvaptan (Side Effects)

Increased thirst, xerostomia, polyuria, fatigue