Synthesis Reactions (Orgo I + II) Ch 1-23

SN2 reactions are ____ step(s). They are faster with ______ steric hindrance. There is a _______ attack by the nucleophile. They are favored by ______ nucleophiles that usually bear a negative charge. They are favored by polar ______ solvents.

1, less, backside, strong, aprotic

SN1 reactions are _____ step(s). They are faster when the ______ is most stable. They undergo frontside and backside attack, which forms ________. Favored by _______ nucleophiles and polar _____ solvents.

2, carbocation, enantiomers, weak, protic

When weak bases are used, _______ is favored.

substitution

When strong, bulky bases are used, _______ is favored.

E2

Strong nucleophiles and strong bases favor _____ and _____.

SN2, E2

Weak nucleophiles and weak bases favor ______ and ______.

SN1, E1

E1 and E2 reaction speed increases with ______ classification

carbon

E1 favored by polar _____ solvents. Increased R groups increase stability.

aprotic

E2 favored by polar ______ solvents. Increased R groups increase stability.

protic

T/F: Degree of unsaturation is calculated by (diff. of Hs between actual H & max. H)/2

T

T/F: Increased conjugation of double bonds increased the max wavelength

T

T/F: Diene reactivity

T

T/F: Dienophile reactivity

T

T/F: Aromatic compounds need to be completely conjugated, cyclic, and planar (all Cs are sp2 hybridized)

T

T/F: Antiaromatic compounds have 4n pi electrons.

T

All ortho/para directors activate the benzene ring, except halogens.

T

T/F: All meta directors deactivate the benzene ring

T

T/F: Halogens direct ortho/para and deactivate the benzene ring

T