age macular degeneration

AMD

drusen development in macula beneath retina

leading cause of blindness

drusen

lipid, mineral, protein deposits in macula

dry AMD

presence of drusen in macula

slow progression of vision impairment

wet AMD

presence of blood and fluid leaking into retina

rapid progression of vision impairment

vitamins for non-smokers (early dry)

vit C, vit E, copper, zinc

beta-carotene

vitamins for smokers (early dry)

vit C, vit E, copper, zinc

lutein, zeaxanthin

dry treatment options

pegcetacoplan, avacincaptad

valeda light

pegcetacoplan

C3 inhib, intravitreal injection

dry treatment - slows progression

ade = risk of wet AMD

avacincaptad

C5 inhib, intravitreal injection

dry treatment - slows progression

ade = risk of wet AMD

valeda light delivery system

improves visual acuity in dry AMD

photobiomodulation

wet treatment options

anti-VEGF

anti-angiopoietin 2

anti-VEGF agents

afibercept, ranibizumab, bevacizumab, brolucizumab

aflibercept

anti-VEGF fusion protein

intravitreal injection, wet treatment

ranibizumab

anti-VEGF mab

intravitreal injection OR implant, wet treatment

bevacizumab

anti-VEGF mab

intravitreal injection, wet treatment (off label)

brolucizumab

anti-VEGF mab

intravitreal injection, wet treatment

faricimab

anti-VEGF and anti-ang 2

intravitreal injection, wet treatment

verteporfin

iv infusion photodynamic therapy for wet AMD