Intersex Condition Disorders of Sexual Development

Over testicular Disorder

Extremely Rare

Person has both ovarian and testicular tissues

Usually infertile

Used to be called hermaphrodites

Congenital Adrenal Hyperplasia (CAH)

Gene mutations leads to impaired steroid metabolism

Adrenal glands secrete insufficient amount of steroids that control salt and water balance (fatal if untreated)

Adrenals also secrete high levels of T

In XX—> high T causes partial masculinization of genitals

Does not affect XY individuals/ men

Androgen Insensitivity Syndrome

XY individuals

X-linked recessive gene results in malfunctioning T receptor

Male internal tract fails to develop bc Wolffian ducts need T to develop; female tract fails to develop bc testes secret anti-Mullerian hormone

External genitalia usually look female at birth but testes remain inside body

Usually identify as female

5-Alpha Reductase Deficiency

At puberty, T increases muscle mass, growth of penis & scrotum, theses descend, voice depends, onset of sperm & ejaculation

At puberty, dihydroT mediates changes that are scant or absentt in this population