Practical 8: Synthesis of Aspirin

Flashcards about Aspirin Synthesis and Analysis

Aspirin Purification Techniques

Laboratory techniques like filtration, recrystallization, and drying.

Aspirin Yield Determination

Calculations to determine the yield of synthesized aspirin.

Aspirin Purity Test

Aspirin purity test using ferric chloride (FeCl₃).

Chromatography

Used to identify reaction products.

Aspirin (Acetylsalicylic Acid)

An enormously successful drug used to reduce pain, fever, and inflammation; also an anti-thrombotic agent.

Aspirin Preparation

Reaction of salicylic acid (2-hydroxybenzoic acid) and acetic anhydride.

Aspirin Chemical Composition

An ester of acetic acid and the phenol group of salicylic acid.

Esterases

Catalyze the hydrolysis of aspirin in the body.

Primary Purpose of Experiment

Monitors the base hydrolysis of aspirin using UV-Vis spectroscopy.

Ferric Chloride Test

Used to detect the presence of salicylic acid, a common impurity in aspirin, indicated by a purple colour.

Chromatography

Separates compounds based on their interactions with stationary and mobile phases.

Stationary Phase

A solid or liquid that adsorbs or dissolves the mixture being separated.

Mobile Phase

A liquid or gas that moves over the stationary phase.

Four Main Types of Chromatography

Paper Chromatography, Thin Layer Chromatography, Gas Chromatography, Liquid Chromatography