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What happens when a helper T cell meets a circulating B cell in the lymph node?
B cells that recognize the same pathogen as the T cell become activated, divide, and differentiate.
What are the outcomes of B cell differentiation based on cytokine signals from helper T cells?
Some B cells differentiate into antibody-secreting plasma cells, some become memory B cells, and others undergo further refinements to their B-cell receptor.
What is somatic hypermutation and selection in B cell differentiation?
Somatic hypermutation and selection generate B cells with a higher affinity for the antigen, a process called affinity maturation.
What is isotype switching in B cells?
Isotype switching is the recombination of heavy chain constant region genes, resulting in a different heavy chain type.
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