ch21 anti inflammatory antipyretics analgesics

Antipyretic properties of anti inflammatory and analgesic drugs

these drugs inhibit prostaglandin synthesis in CNS and affect action of hypothalamic heat regulation center

Role of prostaglandins in inflammation

these are hormone-like substances that modulate inflammation, initiating action potentials along sensory nerve fibers or sensitizing pain receptors

dangers of aspirin use

dangers include possible massive GI hemorrhage, dyspepsia, nausea and vomiting, and occult bleeding

Uses of anti-inflammatory drugs

Uses of these drugs include treating rheumatoid arthritis, osteoarthritis, arthritis, moderate pain, and fever

Side effects of anti-inflammatory drugs

side effects include dizziness, nervousness, occult blood loss, peptic ulcers, GI bleeding

The broad classifications of analgesics

broadly classed as either nonopioid analgesics or opioid analgesics

Function of naturally occurring opioids and their receptors

these substances bind to opioid receptors which block pain transmission

Rationale behind narcotic analgesic usage

these drugs are effective for almost all types of moderate to severe pain and as antipertussives, also mimic endogenous opioids

Problems with use of narcotic analgesics

these drugs may cause respiratory depression and physical and psychological dependence

Buprenorphine mechanism of action

drug causes dose-related analgesia because of high affinity for mu-opioid receptors and antagonization of kappa opiate receptors

Fentanyl mechanism of action

drug is an agonist of mu opioid receptors and is 50-100 times more potent than morphine

Indications of methadone

used to treat moderate-severe chronic pain and opioid addiction