10: hippocampus 2

importance of intermediate hippocampus

substates of place learning and links to behaviour control converge here

it is critical for behaviour based on rapid place learning

what kind of place learning is the hippocampus relevant for?

it is relevant for rapid place learning but not incremental

functional integration in the intermediate hippocampus

thís is required for performance based upon rapid learning

intermediate is sufficient but not required - when it is removed there is impaired performance displaying that functional integration is required

if there is no functional integration there is then impaired performance on rapid spatial learning

implications of hippocampal overactivity from temporal to intermediate hippocampus?

thís may drive projections to the prefrontal cortex and subcortical sites, including dopaminergic inputs

thís may cause: psychosis related behavioural disruptions related to dopamine hyper function

interference with fronto-striatal attentional and executive mechanisms

relationship between hippocampal activity and cognitive performance

the more active the hippocampus is, the worse their cognitive defcits in SZ patients are