immunology (1st nonspecific immunity)

_____ immunity is characterized by immediate action, limited specificity.

Innate immunity system

_____ defense is characterized by epithelial (physcial) and biochemical defenses.

Innate immunity first line of defense

Inflammations, cytokines and products of compliment activation.

Antiviral defense: type 1 interferons act on infected and uneffected cells which activate enzymes that degrade viral dna as well as inhibiting viral replication.

Reactions of innate immunity.

Phagocytes such as (neutrophiles, marcophages, and monocytes), NK Cells( kill viruses), compliment system, C Reactive protien, cytokines, inflammation.

Innate immunity second line of defense.

are located on all WBCs and are receptors to pathogen associated molecular patters (PAMPS)

Pattern Recognition Receptors (PRR)

kinases, lactins, monnose type molecules, Toll like recpeters in membranes of phagocytes.

Types of PRRs

which type of PRR detects ingested molecules, and detect RNA and DNA from viruses

Activates transcription factors by this activates mediators of Cytokines, interferons, which promote lmphocyteic activation.

Endosomal toll receptors.

detects mircoial polysaccerides, leading to phagocytosis and inflammatory reactions.

C Type lectin receptors on plasma membrane of macrophages.

One the surface on neutrophils/ marocphages what recognixe short bacetial peptides, recognize and stimulates recognition of lymphocoytes.

G-Protien coupled receptros.

Moelcuels shated by mircoorganism/pathogens that act as red flags and singal WBcs for innate immunity, and act as an eraly invasion of invasion.

Pathogens-associated molecules patterns(PAMPS).

26 Blood protines that destory bacettia and certian virsus, comes from heoatocytes/ lymphocytes/ monocytes. These prtoens act as a casacade.

the compliment system.

Compliment system kills pathogen directly, and is known as the final step in the compliment system.

recruiting inflammatory cells, and triggering cytokines release.

Membrane attack complex

C1q frist compliment of compliment cascade directly attaching on pathogen surface and antigen: antibody complex protien.

Classicla pathway.

Spontaneous activation of compliment component binding to surface of an antigen.

Alternative pathway.