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Chapter 3: Senses and Perception

Objectives of this Chapter:

  • I will be able to know about vision

  • I will be able to know about hearing

  • I will be able to know about taste and smell

  • I will be able to know about touch and pain

Vision

  • Vision involves around 30% of the human brain

It all starts with light

  • Vision begins with light going through the cornea

    • The cornea does around 75% of the focusing

  • The lens then adjusts the focus

    • The shape of the lens is altered by muscles behind the iris so near or far objects can be brought into focus on the retina

  • Retina: a sheet of photoreceptors in the back of the eye

    • The cornea & lens combine to produce image onto the retina

  • Signals are sent via the optic nerve to parts of the brain that process images and allow us to see

    • Retinal image is reversed in the brain to look right-side up

  • The size of the pupil controls how much light enters the eye

    • Pupil: a hole in the eye that allows light to enter

    • Iris: the muscled ring around the eye that controls the size of the pupil

  • Binocular vision: vision that utilizes two eyes

    • This is what primates have

  • Optic Chiasm: the X-shaped structure formed at the point below the brain where the two optic nerves cross over each other

    • Visual signals pass from the optic nerve to the optic chiasm

  • Each half of the cerebrum is responsible for processing information from the opposite half of the body (left hemisphere to right side, vice versa)

  • Photoreceptors: neurons specialized to turn light into electrical signals

    • There are approximately 125 million photoreceptors in each eye

    • 2 major types: rods and cones

      • Rods: extremely sensitive to light & allow us to see in dim light but do not convey color

      • Cones: need a bright enough light but give acute details and convey color

        • 3 cones: red, green, blue

          • Each sensitive to a different range of colors

        • Cones work in combination to convey information about all visible colors

  • Fovea: area of the retina where the light is focused

  • Macula: the area in the retina around the fovea critical for reading and driving

  • The retina has 3 layers

    • 1st layer: rods and cones

    • 2nd layer: interneurons that relay information

    • 3rd layer: ganglia that make optic nerve

  • Receptive Field: region of visual space providing input to neuron

    • Center of the retina is most receptive area while the sides are less receptive

How Visual Information is processed

  • A visual cell’s receptive field is activated when light hits the center and not at the sides

    • If light hits all the parts, the cell responds weakly

  • Visual processing starts by comparing the amount of light striking any tiny region of the retina with the amount of surrounding light

  • Visual information goes in this pathway:

    • retina → lateral geniculate nucleus in the thalamus → primary visual cortex (PVC)

  • Cells above and below the middle layer of PVC respond differently than the middle layer

    • Cells in the layers above and below prefer stimuli in shape of bars or edges and those at a particular angle

  • Signals are fed into at least 3 processing systems

    • First system processes information about shape

    • Second system processes color information

    • Third system processes information about movement, location, spatial organization

  • Perception of movement, depth, perspective, relative size and movement, shading, and gradations in texture primarily depend on contrasts in light intensity rather than color

Research leads to more effective treatment

  • Strabismus: a condition where the eyes are not properly aligned

  • Extensive genetic studies and the use of model organisms make it possible to make gene/stem cell therapy or discover new drugs for treatments

Hearing

  • Hearing allows for communication and information for survival

  • External ear: the collective name for the visible portion of the ear (pinna) and the auditory canal

    • This is the initial collector of sound waves

  • Tympanic membrane/Eardrum: thin tissue that produces and sends sound vibrations to the middle ear

    • Eardrum makes the ossicles vibrate and amplify its vibration

      • Ossicles: three bones in the middle ear (malleus, incus, stapes) that amplifies the vibrations produced by the eardrum

  • The stapes pushes on a part called the oval window to send pressure waves to cochlea

    • Cochlea: snail-shaped organ in the inner ear that converts mechanical vibrations from the eardrum and ossicles to electrical signals to be sent to the brain

      • An important part of the cochlea is the basilar membrane

        • basilar membrane: a membrane containing cells called hair cells that react to different frequencies/pitches

          • Hair cells are topped with stereocilia that are deflected by the overlying tectorial membrane

          • Hair cells convert mechanical vibration to electrical signals and excite the auditory nerve

  • auditory nerve: one of the 12 cranial nerves that is responsible for carrying auditory information from the cochlea to the brain

    • Each nerve fiber of the auditory nerve contains information about a different frequency to the brain

  • Superior temporal gyrus/auditory cortex: the part of the brain that analyzes auditory information

    • In the auditory cortex, adjacent neurons respond to tones of similar frequency

      • The neurons each specialize in different combos of tones

    • Other neurons combine information to recognize the sound

    • The left auditory cortex is specialized for speech

Taste and smell

Taste

  • Taste is focused on distinguishing chemicals that have sweet, salty, sour, bitter, or umami (savory) taste

  • Tastants: chemicals present in foods that give them flavor

    • Tastants are detected by taste buds

      • taste buds: the sensory organs responsible for obtaining information about taste

        • Taste buds are embedded in papillae

        • Taste buds are found on the tongue, the back of the mouth, and on the palate

        • 1 taste bud= 50-100 sensory cells

  • These sensory cells are stimulated by sugars, salts, acids

  • When stimulated, sensory cells send impulses along the cranial nerves → taste regions in brain → thalamus

    • The thalamus sends it to a specific area of cerebral cortex which makes us conscious of taste

Smell

  • Odorants are detected by sensory neurons in a small patch of mucus membrane on the roof of the nose

  • Axons of the cells pass through holes in the bone and enter 2 olfactory bulbs against the underside of the brain’s frontal lobe

    • Olfactory bulbs: a rounded structure that contains neurons receiving information about odors detected by sensory neurons on the roof of the nose

  • Odorants stimulate receptors and initiate a neural response

    • Odorants can act on more than 1 receptor but to varying degrees

  • The pattern of activity is sent to the olfactory bulb where other neurons are activated to form a spatial map of odor

  • Neural activity passes to the primary olfactory cortex at the back of the underside of the frontal lobe

    • This information then passes to the orbital cortex to combine with taste information to make the perception of flavor

Touch and Pain

Touch

  • Touch: the sense by which we determine the characteristics of objects (size, shape, texture)

  • In areas with hairy skin, some touch receptors consist of webs of neuron endings wrapped around the base of hair

    • Signals from these receptors pass through sensory nerves to the spinal cord

  • The spinal cord passes information about touch to the thalamus and to the sensory cortex

  • The transmission of information about touch is highly topographic

    • topographic: meaning the body is represented in an orderly fashion based on sensory requirements at different levels of the nervous system

  • Larger areas of the cortex are made for more sensitive areas like the hands and lips while smaller cortex areas represent less sensitive parts of the body

  • Different parts of the body vary in sensitivity to tactile and painful stimuli

    • This is largely based on the number and distribution of receptors

      • E.g: the cornea is several hundreds of times more sensitive to painful stimuli than the soles of feet

    • The fingertips are good at touch discrimination but the torso is not

  • Two-point threshold: distance between 2 points of skin in order for the person to distinguish 2 stimuli from one

    • Neurologists measure sensitivity by determining the two-point threshold

    • The acuity of the two-point threshold is greatest where there are most nerves

Pain

  • Nociceptors: sensory fibers that respond to tissue-damaging stimuli and cause pain

    • Different subsets of nociceptors make molecules that are responsible for responses to painful, thermal, mechanical, or chemical stimulation

  • Tissue injury releases many different chemicals at the site of damage/inflammation

  • Prostaglandins: enhance sensitivity of receptors to tissue damage and induces more pain

    • also contributes to allodynia

  • Allodynia: triggering of pain response from stimuli which doesn’t usually provoke pain

  • Persistent pain leads to changes in the nervous system that amplify and prolong pain

Sending and Receiving Pain and Itch Messages

  • Pain and itch messages are transmitted to the spinal cord through small myelinated and unmyelinated ( C ) fibers

    • Myelinated fibers are pain sensitive and evoke sharp and fast pain

    • Unmyelinated/C fibers are slower in onset and cause more dull, diffuse pain

  • Impulses relayed to several brain structures including the thalamus and cerebral cortex

    • Thalamus and cerebral cortex involved in making the pain/itch message into a conscious experience

  • Factors like the setting and emotional impact contribute to the overall response to a painful experience

  • Pain messages can be suppressed by neurons originating from gray matter in the brainstem

    • They suppress pain by inhibiting the transmission of pain signals from the dorsal horn of the spinal cord to higher brain areas

  • Some systems use natural chemicals: endogenous opioids or endorphins

    • Endorphins very similar to morphine

    • After a technique for putting opioids in the spine was successfully performed in animals, this treatment began in humans.

      • Now, this technique is common in treating pain after surgery.

  • There is no area in the brain specifically for pain

    • Emotional and sensory components constitute a mosaic of activity leading to pain

Chapter 3: Senses and Perception

Objectives of this Chapter:

  • I will be able to know about vision

  • I will be able to know about hearing

  • I will be able to know about taste and smell

  • I will be able to know about touch and pain

Vision

  • Vision involves around 30% of the human brain

It all starts with light

  • Vision begins with light going through the cornea

    • The cornea does around 75% of the focusing

  • The lens then adjusts the focus

    • The shape of the lens is altered by muscles behind the iris so near or far objects can be brought into focus on the retina

  • Retina: a sheet of photoreceptors in the back of the eye

    • The cornea & lens combine to produce image onto the retina

  • Signals are sent via the optic nerve to parts of the brain that process images and allow us to see

    • Retinal image is reversed in the brain to look right-side up

  • The size of the pupil controls how much light enters the eye

    • Pupil: a hole in the eye that allows light to enter

    • Iris: the muscled ring around the eye that controls the size of the pupil

  • Binocular vision: vision that utilizes two eyes

    • This is what primates have

  • Optic Chiasm: the X-shaped structure formed at the point below the brain where the two optic nerves cross over each other

    • Visual signals pass from the optic nerve to the optic chiasm

  • Each half of the cerebrum is responsible for processing information from the opposite half of the body (left hemisphere to right side, vice versa)

  • Photoreceptors: neurons specialized to turn light into electrical signals

    • There are approximately 125 million photoreceptors in each eye

    • 2 major types: rods and cones

      • Rods: extremely sensitive to light & allow us to see in dim light but do not convey color

      • Cones: need a bright enough light but give acute details and convey color

        • 3 cones: red, green, blue

          • Each sensitive to a different range of colors

        • Cones work in combination to convey information about all visible colors

  • Fovea: area of the retina where the light is focused

  • Macula: the area in the retina around the fovea critical for reading and driving

  • The retina has 3 layers

    • 1st layer: rods and cones

    • 2nd layer: interneurons that relay information

    • 3rd layer: ganglia that make optic nerve

  • Receptive Field: region of visual space providing input to neuron

    • Center of the retina is most receptive area while the sides are less receptive

How Visual Information is processed

  • A visual cell’s receptive field is activated when light hits the center and not at the sides

    • If light hits all the parts, the cell responds weakly

  • Visual processing starts by comparing the amount of light striking any tiny region of the retina with the amount of surrounding light

  • Visual information goes in this pathway:

    • retina → lateral geniculate nucleus in the thalamus → primary visual cortex (PVC)

  • Cells above and below the middle layer of PVC respond differently than the middle layer

    • Cells in the layers above and below prefer stimuli in shape of bars or edges and those at a particular angle

  • Signals are fed into at least 3 processing systems

    • First system processes information about shape

    • Second system processes color information

    • Third system processes information about movement, location, spatial organization

  • Perception of movement, depth, perspective, relative size and movement, shading, and gradations in texture primarily depend on contrasts in light intensity rather than color

Research leads to more effective treatment

  • Strabismus: a condition where the eyes are not properly aligned

  • Extensive genetic studies and the use of model organisms make it possible to make gene/stem cell therapy or discover new drugs for treatments

Hearing

  • Hearing allows for communication and information for survival

  • External ear: the collective name for the visible portion of the ear (pinna) and the auditory canal

    • This is the initial collector of sound waves

  • Tympanic membrane/Eardrum: thin tissue that produces and sends sound vibrations to the middle ear

    • Eardrum makes the ossicles vibrate and amplify its vibration

      • Ossicles: three bones in the middle ear (malleus, incus, stapes) that amplifies the vibrations produced by the eardrum

  • The stapes pushes on a part called the oval window to send pressure waves to cochlea

    • Cochlea: snail-shaped organ in the inner ear that converts mechanical vibrations from the eardrum and ossicles to electrical signals to be sent to the brain

      • An important part of the cochlea is the basilar membrane

        • basilar membrane: a membrane containing cells called hair cells that react to different frequencies/pitches

          • Hair cells are topped with stereocilia that are deflected by the overlying tectorial membrane

          • Hair cells convert mechanical vibration to electrical signals and excite the auditory nerve

  • auditory nerve: one of the 12 cranial nerves that is responsible for carrying auditory information from the cochlea to the brain

    • Each nerve fiber of the auditory nerve contains information about a different frequency to the brain

  • Superior temporal gyrus/auditory cortex: the part of the brain that analyzes auditory information

    • In the auditory cortex, adjacent neurons respond to tones of similar frequency

      • The neurons each specialize in different combos of tones

    • Other neurons combine information to recognize the sound

    • The left auditory cortex is specialized for speech

Taste and smell

Taste

  • Taste is focused on distinguishing chemicals that have sweet, salty, sour, bitter, or umami (savory) taste

  • Tastants: chemicals present in foods that give them flavor

    • Tastants are detected by taste buds

      • taste buds: the sensory organs responsible for obtaining information about taste

        • Taste buds are embedded in papillae

        • Taste buds are found on the tongue, the back of the mouth, and on the palate

        • 1 taste bud= 50-100 sensory cells

  • These sensory cells are stimulated by sugars, salts, acids

  • When stimulated, sensory cells send impulses along the cranial nerves → taste regions in brain → thalamus

    • The thalamus sends it to a specific area of cerebral cortex which makes us conscious of taste

Smell

  • Odorants are detected by sensory neurons in a small patch of mucus membrane on the roof of the nose

  • Axons of the cells pass through holes in the bone and enter 2 olfactory bulbs against the underside of the brain’s frontal lobe

    • Olfactory bulbs: a rounded structure that contains neurons receiving information about odors detected by sensory neurons on the roof of the nose

  • Odorants stimulate receptors and initiate a neural response

    • Odorants can act on more than 1 receptor but to varying degrees

  • The pattern of activity is sent to the olfactory bulb where other neurons are activated to form a spatial map of odor

  • Neural activity passes to the primary olfactory cortex at the back of the underside of the frontal lobe

    • This information then passes to the orbital cortex to combine with taste information to make the perception of flavor

Touch and Pain

Touch

  • Touch: the sense by which we determine the characteristics of objects (size, shape, texture)

  • In areas with hairy skin, some touch receptors consist of webs of neuron endings wrapped around the base of hair

    • Signals from these receptors pass through sensory nerves to the spinal cord

  • The spinal cord passes information about touch to the thalamus and to the sensory cortex

  • The transmission of information about touch is highly topographic

    • topographic: meaning the body is represented in an orderly fashion based on sensory requirements at different levels of the nervous system

  • Larger areas of the cortex are made for more sensitive areas like the hands and lips while smaller cortex areas represent less sensitive parts of the body

  • Different parts of the body vary in sensitivity to tactile and painful stimuli

    • This is largely based on the number and distribution of receptors

      • E.g: the cornea is several hundreds of times more sensitive to painful stimuli than the soles of feet

    • The fingertips are good at touch discrimination but the torso is not

  • Two-point threshold: distance between 2 points of skin in order for the person to distinguish 2 stimuli from one

    • Neurologists measure sensitivity by determining the two-point threshold

    • The acuity of the two-point threshold is greatest where there are most nerves

Pain

  • Nociceptors: sensory fibers that respond to tissue-damaging stimuli and cause pain

    • Different subsets of nociceptors make molecules that are responsible for responses to painful, thermal, mechanical, or chemical stimulation

  • Tissue injury releases many different chemicals at the site of damage/inflammation

  • Prostaglandins: enhance sensitivity of receptors to tissue damage and induces more pain

    • also contributes to allodynia

  • Allodynia: triggering of pain response from stimuli which doesn’t usually provoke pain

  • Persistent pain leads to changes in the nervous system that amplify and prolong pain

Sending and Receiving Pain and Itch Messages

  • Pain and itch messages are transmitted to the spinal cord through small myelinated and unmyelinated ( C ) fibers

    • Myelinated fibers are pain sensitive and evoke sharp and fast pain

    • Unmyelinated/C fibers are slower in onset and cause more dull, diffuse pain

  • Impulses relayed to several brain structures including the thalamus and cerebral cortex

    • Thalamus and cerebral cortex involved in making the pain/itch message into a conscious experience

  • Factors like the setting and emotional impact contribute to the overall response to a painful experience

  • Pain messages can be suppressed by neurons originating from gray matter in the brainstem

    • They suppress pain by inhibiting the transmission of pain signals from the dorsal horn of the spinal cord to higher brain areas

  • Some systems use natural chemicals: endogenous opioids or endorphins

    • Endorphins very similar to morphine

    • After a technique for putting opioids in the spine was successfully performed in animals, this treatment began in humans.

      • Now, this technique is common in treating pain after surgery.

  • There is no area in the brain specifically for pain

    • Emotional and sensory components constitute a mosaic of activity leading to pain

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