Unit 2- Ch. 10 Antimicrobial- Antivirals, Antiprotozoals, and Anthelminthics

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28 Terms

1
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Quinine has traditionally been used to treat what infectious disease?
Malaria
2
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Artemisinin is used to treat what infectious disease?
Malaria
3
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Metronidazole is used to treat what type of microbial infections?
Fungal infections
4
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What is the mechanism of action of mebendazole?
Microtubule inhibition
5
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Pyrantel is used to treat what type of microbial infection?
Helminthic
6
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Ivermectin is used to treat what type of microbial infection?
Helminthic
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What is the mechanism of action of pyrantel?
Muscle paralysis
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What is the mechanism of action of ivermectin?
Muscle paralysis
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Amantadine is used to treat what type of microbial infection?
Viral
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What is the mechanism of action of amantadine?
Prevent viral entry into the cell
11
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Acyclovir is used to treat what type of microbial infection?
Viral
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Ribavirin is used to treat what type of microbial infection?
Viral
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Zidovudine (AZT) is used to treat what type of microbial infection?
Viral
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What is the mechanism of action of acyclovir?
Inhibits viral nucleic acid synthesis
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What is the mechanism of action of ribavirin?
Inhibits viral nucleic acid synthesis
16
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What is the mechanism of action of zidovudine (AZT)?
Inhibits viral nucleic acid synthesis
17
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Zanamivir is used to treat what type of microbial infection?
Viral
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Oseltamivir is used to treat what type of microbial infection?
Viral
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What is the mechanism of action of zanamivir?
Inhibition of viral assembly and release
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What is the mechanism of action of oseltamivir?
Inhibition of viral assembly and release
21
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What is the mechanism of action of quinine?
Interferes with the parasite's ability to break down and digest hemoglobin.
22
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What is the mechanism of action of artemisinin?
Produces a free-radical intermediates that poison one or more essential malarial protein(s).
23
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What is the mechanism of quinine?
Interferes with parasite digestion of hemoglobin.
24
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What is the mechanism of action of chloroquine?
Interferes with parasite digestion of hemoglobin.
25
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What is the mechanism of action of primaquine?
Interferes with parasite digestion of hemoglobin.
26
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What is the mechanism of action of albendazole?
Microtubule inhibition
27
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What is the mechanism of action of quinacrine?
Likely inhibits transcription and translation of DNA and may also interfere with cellular energy production.
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What is the mechanism of action of metronidazole?
Oxidizes parasite DNA causing strand breakage and ultimately cell death.