RBC Data

generation steps

burst-forming unit (1 week) to colony-forming unit (1 week); no visual difference

maturation steps

(1) pronormoblast, (2) basophilic normoblast, (3) polychromatic normoblast, (4) orthochromic normoblast, (5) reticulocyte, (6) mature RBC

erythron

entirety of erythroid cells in the body (circulation, bone marrow, extramedullary sites)

RBC mass

all RBCs in circulation

hormone that triggers RBC production

erythropoietin

production location of erythropoietin

kidney; when it detects low O2

anisocytosis

variation in RBC size

poikilocytosis

variation in cells shapes

what determines size of RBC

excess HGB or delayed cytoplasm development

what causes excess HGB

impaired DNA replication

what causes delayed cytoplasm development

impaired RNA synthesis

substances permeable to RBC membrane

O2, CO2, HCO3-, Cl-, H2O, glucose

ions that need pumps to get into RBCs

Na+, K+, Ca2+

RBC lifespan

120 days

spherocytes lifespan

20-30 days

diagnosis of hereditary spherocytosis

Osmotic fragility test